{"id":"W1936337345","doi":"10.1080/21505594.2015.1062211","title":"A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases","year":2015,"lang":"en","type":"review","venue":"Virulence","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Biology; Pathogen; Host (biology); Pattern recognition receptor; Host–pathogen interaction; Tug of war; Computational biology; Pathogen-associated molecular pattern; Immunology; Immunity; Immune system; Virulence; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009635852,0.0003136362,0.0009563321,0.00009130371,0.000350233,0.00002327485,0.0006510405,0.0001935704,0.0000173444],"category_scores_gemma":[0.0001355359,0.0001297906,0.0005092147,0.0001727717,0.0009345755,0.00003587123,0.0001999849,0.0002905301,0.00001496985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003361417,"about_ca_system_score_gemma":0.0005006107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001982674,"about_ca_topic_score_gemma":0.00001599388,"domain_scores_codex":[0.9980995,0.0005865978,0.0007830557,0.0002378411,0.00005366128,0.0002393237],"domain_scores_gemma":[0.9969758,0.001804026,0.0006013852,0.000442962,0.0001600578,0.00001581294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002471489,0.0002368316,0.00004635471,0.00413211,0.003000763,3.207223e-7,0.001393323,0.000002120189,0.001964695,0.001586179,0.00008912275,0.9873011],"study_design_scores_gemma":[0.004005789,0.0006621003,0.001304304,0.01305024,0.006001549,0.00006652786,0.001768482,0.00001910461,0.001273735,0.0003419094,0.9707108,0.0007955268],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002639572,0.9939364,0.0007639084,0.00003849061,0.0003153268,0.001407909,0.000824407,0.00001618613,0.00005783316],"genre_scores_gemma":[0.04261754,0.956425,0.00003317102,0.00003701694,0.00003841619,0.0004799253,0.0001354688,0.00002821518,0.0002052816],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9865055,"threshold_uncertainty_score":0.5292706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.133123151650341,"score_gpt":0.3583920380292347,"score_spread":0.2252688863788938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}