{"id":"W1936708715","doi":"10.4049/jimmunol.173.5.3297","title":"Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by <i>Leishmania mexicana</i> Amastigotes: The Role of Cysteine Peptidases and the NF-κB Signaling Pathway","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Amastigote; Leishmania mexicana; Biology; Molecular biology; Lipopolysaccharide; IκBα; NF-κB; Leishmania; Biochemistry; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002146932,0.0001789895,0.0006036405,0.000139714,0.0002464898,0.00001244906,0.0002722915,0.00008176256,0.00001285729],"category_scores_gemma":[0.00112616,0.00008152943,0.0001443698,0.0002142516,0.001176734,0.0001375876,0.0001462207,0.0006688333,0.000002212113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008216024,"about_ca_system_score_gemma":0.0001716738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006120648,"about_ca_topic_score_gemma":0.00004763345,"domain_scores_codex":[0.9977803,0.0005249868,0.0008013407,0.0001351576,0.0004836803,0.0002745906],"domain_scores_gemma":[0.9976144,0.0004776288,0.0009251379,0.0003766276,0.0005617488,0.00004447818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002119184,0.0001417976,0.0001810323,0.00003876776,0.0005128384,0.00001094033,0.003637394,0.00006972255,0.9905075,0.0004933406,0.0001106975,0.002176738],"study_design_scores_gemma":[0.003420235,0.001454535,0.0009195706,0.0003152573,0.0002478797,0.0009277325,0.009310812,0.00001290593,0.9816139,0.00157948,0.0001271943,0.00007054426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760861,0.01328095,0.0001153601,0.009789295,0.0001280509,0.0004661526,0.00001041534,0.000008916204,0.0001147578],"genre_scores_gemma":[0.9974684,0.002039368,0.00008875163,0.0001262503,0.0001974846,0.000009020971,0.000001457012,0.00002045135,0.00004887628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02138224,"threshold_uncertainty_score":0.4335724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238539746226957,"score_gpt":0.2426298808496672,"score_spread":0.2302444833873976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}