{"id":"W1936708715","doi":"10.4049/jimmunol.173.5.3297","title":"Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by <i>Leishmania mexicana</i> Amastigotes: The Role of Cysteine Peptidases and the NF-κB Signaling Pathway","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Amastigote; Leishmania mexicana; Biology; Molecular biology; Lipopolysaccharide; IκBα; NF-κB; Leishmania; Biochemistry; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196464,0.0004887254,0.0002974331,0.0001349439,0.0001169665,0.0002816965,0.0002379432,0.000243103,0.0007781539],"category_scores_gemma":[0.00008386886,0.000141568,0.000272581,0.0001382468,0.0002234666,0.0001595714,0.0001304418,0.0004912642,0.0003108404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272723,"about_ca_system_score_gemma":0.0002098495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005369334,"about_ca_topic_score_gemma":0.0005279032,"domain_scores_codex":[0.9999053,0.00001785326,0.00001112044,0.00001436091,0.00001697905,0.00003447236],"domain_scores_gemma":[0.9999372,0.000009721635,0.00001807451,0.000007154509,0.000008561145,0.00001925547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001523155,0.00002500772,0.0000476595,0.00004924291,0.000003427405,0.00001852092,0.000004937526,0.00001716365,0.9991181,0.00002226304,0.00001578934,0.0005254566],"study_design_scores_gemma":[0.0000381778,0.0004338352,0.002069618,0.000007535479,0.0000134242,0.0001334332,0.00001208116,0.0003375295,0.9955912,0.00001698386,0.001342589,0.00000361236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929519,0.003426175,0.001855561,0.0001472153,0.00002784474,0.00003936043,0.000356061,0.0001080527,0.001087828],"genre_scores_gemma":[0.9946524,0.001339117,0.001769779,0.00007728443,0.00001923725,0.0000628704,0.0006189902,0.0000199462,0.001440404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007781539,"threshold_uncertainty_score":0.002603233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238539746226957,"score_gpt":0.2426298808496672,"score_spread":0.2302444833873976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}