{"id":"W1936789375","doi":"10.4049/jimmunol.1000890","title":"<i>N</i>-Ethyl-<i>N</i>-Nitrosourea–Induced Mutation in Ubiquitin-Specific Peptidase 18 Causes Hyperactivation of IFN-αβ Signaling and Suppresses STAT4-Induced IFN-γ Production, Resulting in Increased Susceptibility to <i>Salmonella</i> Typhimurium","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre","funders":"McGill University Health Centre; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Canada Research Chairs; National Heart, Lung, and Blood Institute; McGill University","keywords":"Biology; STAT4; Missense mutation; Mutation; Gene; Phosphorylation; Ubiquitin; STAT1; Salmonella; Cytokine; Cancer research; Interferon; Molecular biology; Microbiology; Genetics; stat; Bacteria; STAT3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071908,0.000325859,0.0001394979,0.0001937744,0.00008762633,0.0001382167,0.0001555616,0.0002011313,0.001066827],"category_scores_gemma":[0.00007772392,0.000154386,0.0002055793,0.00008136244,0.0002307715,0.00007352744,0.0001121449,0.000323169,0.0002248915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181366,"about_ca_system_score_gemma":0.0001606051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006471857,"about_ca_topic_score_gemma":0.001115422,"domain_scores_codex":[0.9998958,0.00002075871,0.00001116583,0.00002271192,0.00002211075,0.00002751069],"domain_scores_gemma":[0.9998851,0.00001776376,0.00005172446,0.00001848039,0.000006675801,0.000020284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001170509,0.00002237126,0.0001340995,0.000008682269,0.000004831742,0.00003690649,0.000003246744,0.00005145176,0.9991608,0.00005207245,0.00001806645,0.0003903692],"study_design_scores_gemma":[0.0000247032,0.000365709,0.002609877,0.00000399042,0.00001437233,0.0003051484,0.00001040116,0.000550824,0.9952201,0.00003572382,0.0008558392,0.000003264448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997915,0.0001583598,0.001010854,0.00005195196,0.00001509756,0.00001290428,0.0001301169,0.00004783429,0.0006580079],"genre_scores_gemma":[0.9969239,0.0002148987,0.001292182,0.00004012488,0.000006620294,0.00001254993,0.0002574146,0.00002024875,0.001231996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001066827,"threshold_uncertainty_score":0.003568888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159985713421026,"score_gpt":0.2674913664384381,"score_spread":0.2458915093042278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}