{"id":"W1936789375","doi":"10.4049/jimmunol.1000890","title":"<i>N</i>-Ethyl-<i>N</i>-Nitrosourea–Induced Mutation in Ubiquitin-Specific Peptidase 18 Causes Hyperactivation of IFN-αβ Signaling and Suppresses STAT4-Induced IFN-γ Production, Resulting in Increased Susceptibility to <i>Salmonella</i> Typhimurium","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre","funders":"McGill University Health Centre; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Canada Research Chairs; National Heart, Lung, and Blood Institute; McGill University","keywords":"Biology; STAT4; Missense mutation; Mutation; Gene; Phosphorylation; Ubiquitin; STAT1; Salmonella; Cytokine; Cancer research; Interferon; Molecular biology; Microbiology; Genetics; stat; Bacteria; STAT3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002914067,0.0002860421,0.0006447543,0.0006633987,0.0001716971,0.0000249699,0.0003815386,0.0003331744,0.0001181297],"category_scores_gemma":[0.002467141,0.0002256356,0.0000858972,0.0004595166,0.0003086291,0.0003553315,0.0001290688,0.00149662,0.000014334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009504371,"about_ca_system_score_gemma":0.0002157444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001439182,"about_ca_topic_score_gemma":0.00112184,"domain_scores_codex":[0.9960431,0.001746268,0.001341315,0.0003070005,0.0001048379,0.0004574133],"domain_scores_gemma":[0.9965039,0.001531533,0.0008766693,0.0004395328,0.000614201,0.00003420176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007974137,0.0003329453,0.003012621,0.00002635902,0.0001015737,0.00001476855,0.004392907,0.000057074,0.9821702,0.00003086443,0.0001663227,0.001720287],"study_design_scores_gemma":[0.002166957,0.001023028,0.07231328,0.0001682808,0.00003705853,0.0007034991,0.004499512,0.00000245612,0.9184285,0.0001177601,0.000344606,0.0001950076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963858,0.001049832,0.00002450745,0.0009449829,0.001052447,0.0004553767,0.00001190265,0.00001788482,0.00005731148],"genre_scores_gemma":[0.9993872,0.0001840204,0.0001452457,0.00008765014,0.00008261269,0.000009926369,0.00001600675,0.00002955388,0.00005778047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06930066,"threshold_uncertainty_score":0.9201154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159985713421026,"score_gpt":0.2674913664384381,"score_spread":0.2458915093042278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}