{"id":"W1937139133","doi":"10.1002/em.21954","title":"Development of the adverse outcome pathway “alkylation of <scp>DNA</scp> in male premeiotic germ cells leading to heritable mutations” using the <scp>OECD</scp>'s users' handbook supplement","year":2015,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Genetically Modified Organisms Research","field":"Agricultural and Biological Sciences","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Population and Public Health; Carleton University; University of Ottawa; Health Canada","funders":"","keywords":"Adverse Outcome Pathway; Germ cell; DNA repair; Biology; DNA damage; Mutagen; Genetics; DNA; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009245094,0.001267093,0.001086966,0.004269694,0.0008370645,0.00272651,0.002593828,0.002075755,0.04197362],"category_scores_gemma":[0.0108837,0.0009820402,0.001403142,0.002220188,0.000668287,0.002249992,0.003313739,0.001785149,0.03230007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001865451,"about_ca_system_score_gemma":0.008972852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00916643,"about_ca_topic_score_gemma":0.01205124,"domain_scores_codex":[0.993505,0.00141322,0.0006103295,0.0004248616,0.003792381,0.0002541537],"domain_scores_gemma":[0.9887799,0.002200691,0.0008011457,0.001658043,0.006137518,0.0004226719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003393649,0.0003166042,0.001881452,0.007941621,0.00008549947,0.0005956938,0.0006068313,0.003539406,0.02631805,0.01588961,0.4739442,0.4685417],"study_design_scores_gemma":[0.00002433094,0.0001692489,0.0008949042,0.0007374196,0.00003756816,0.0001792846,0.00007053266,0.0004875887,0.01391298,0.001735194,0.9817178,0.00003305743],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.01625724,0.0193682,0.3560731,0.0169667,0.004669135,0.01309504,0.1314845,0.03591816,0.4061679],"genre_scores_gemma":[0.03897726,0.03909159,0.4196033,0.006800137,0.0006153306,0.01019264,0.1739334,0.006749818,0.3040365],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04197362,"threshold_uncertainty_score":0.1404157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.032401135062696,"score_gpt":0.2332018185668149,"score_spread":0.2008006835041188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}