{"id":"W1937225926","doi":"10.1101/gad.912901","title":"Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN","year":2001,"lang":"en","type":"article","venue":"Genes & Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":218,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Tobacco-Related Disease Research Program; U.S. Department of Defense; National Cancer Institute; National Science Foundation; National Institutes of Health; American Cancer Society","keywords":"Ubiquitin; Cell biology; Biology; Ubiquitin ligase; Deubiquitinating enzyme; Regulator; Signal transduction; Transforming growth factor; Proteasome; Ubiquitin-conjugating enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217268,0.00008551265,0.00007306078,0.00002643493,0.00013454,0.00001503058,0.00009298189,0.00004261466,0.000007623414],"category_scores_gemma":[0.00005714411,0.00007066012,0.00002354407,0.00005188907,0.0000331264,0.000002859651,0.00005077284,0.00001561779,7.174211e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001197912,"about_ca_system_score_gemma":0.0000807001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000347035,"about_ca_topic_score_gemma":0.00003003141,"domain_scores_codex":[0.9993774,0.00002817814,0.0001970244,0.0001781163,0.0000923708,0.0001268625],"domain_scores_gemma":[0.9996306,0.00002096917,0.0001016179,0.0001162402,0.00009942173,0.00003116528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005076366,0.00004696779,0.005844937,0.00004987141,0.00004244981,3.905947e-7,0.0002471857,0.00003584115,0.6771293,0.00003677987,0.0002936782,0.3162219],"study_design_scores_gemma":[0.0003766655,0.00007101788,0.03775872,0.00002550617,0.00001495445,0.000006577347,0.0001011456,0.0001774488,0.8706258,0.00005694785,0.09066207,0.0001231683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899931,0.001028287,0.008434443,0.000108111,0.0000467207,0.0002958262,0.000006211247,0.000008851121,0.00007845232],"genre_scores_gemma":[0.986779,0.00008775304,0.01235311,0.00008831193,0.00006642724,0.00007036923,0.0003666096,0.00001186463,0.0001766002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3160987,"threshold_uncertainty_score":0.2881436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04437715544709919,"score_gpt":0.291446078508454,"score_spread":0.2470689230613548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}