{"id":"W1937411730","doi":"10.1186/s12862-015-0450-x","title":"ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1","year":2015,"lang":"en","type":"article","venue":"BMC Evolutionary Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bamfield Marine Sciences Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Association pour la Recherche sur le Cancer","keywords":"Biology; Gene isoform; Gene knockdown; Lizard; MAPK/ERK pathway; Gene; Cell biology; Genetics; Signal transduction; Zoology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003468236,0.0001675791,0.0002017834,0.0001235175,0.00004569062,0.000003955088,0.000114436,0.0002879904,0.00003649874],"category_scores_gemma":[0.0001239916,0.0001574776,0.00006383532,0.0001378458,0.0002501028,0.000009690041,0.0001455341,0.00009815085,0.00001051565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005496764,"about_ca_system_score_gemma":0.0003012247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001158859,"about_ca_topic_score_gemma":0.00008550524,"domain_scores_codex":[0.9986231,0.0002654339,0.0003235146,0.000433317,0.00007807892,0.0002765712],"domain_scores_gemma":[0.9993239,0.00003624474,0.0001132856,0.0002718791,0.0001378238,0.0001168714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007381071,0.0002052741,0.486943,0.00004445033,0.00004792004,0.000003644013,0.00003039284,0.0002870337,0.4810224,0.02057346,0.009756935,0.0003473453],"study_design_scores_gemma":[0.001976673,0.0009901014,0.9205961,0.00001805227,0.00002000224,0.00006050212,0.00006297986,0.0003396221,0.00690714,0.009524182,0.05921,0.0002946946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850196,0.007423031,0.004411951,0.0002234061,0.0007170427,0.0002444926,0.00006993533,0.00001710252,0.001873479],"genre_scores_gemma":[0.9961324,0.00006144985,0.001734303,0.00005850007,0.0003957542,0.0000440271,0.0003823182,0.00001387985,0.001177406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4741153,"threshold_uncertainty_score":0.642175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03876393534504356,"score_gpt":0.2597658214231273,"score_spread":0.2210018860780837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}