{"id":"W1937800286","doi":"10.1111/cts.12275","title":"Sodium Channel Inhibitors Reduce DMPK mRNA and Protein","year":2015,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario; University of Ottawa","funders":"Institute of Genetics; U.S. Public Health Service; Canadian Institutes of Health Research; University of Ottawa; Spinal Muscular Atrophy Foundation","keywords":"Sodium channel; Messenger RNA; Medicine; Pharmacology; Computational biology; Biology; Chemistry; Bioinformatics; Internal medicine; Sodium; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00062298,0.00006096163,0.00007448201,0.00002202162,0.00009835768,0.00002132338,0.00006995213,0.00008471093,0.000006267418],"category_scores_gemma":[0.0002058886,0.00004973938,0.0000247712,0.00008679825,0.0007849454,0.000008869643,0.00003448423,0.00007056855,0.000005814565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":9.427416e-7,"about_ca_system_score_gemma":0.0001410154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004779614,"about_ca_topic_score_gemma":0.000007705497,"domain_scores_codex":[0.9992255,0.00003968427,0.0001725845,0.0003168199,0.0001277604,0.0001176567],"domain_scores_gemma":[0.9995862,0.00001525968,0.00003037701,0.00008040925,0.00007981888,0.0002079509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001304572,0.0003921516,0.07093659,0.00003391965,0.00003548959,0.00001218652,0.0005738098,0.00005339343,0.8583447,0.0155461,0.005410294,0.04735675],"study_design_scores_gemma":[0.01195627,0.004567425,0.2313177,0.00009350251,0.00006844177,0.0003237889,0.0003790254,0.002966374,0.222052,0.05794398,0.4667373,0.001594113],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927232,0.0003627282,0.001545505,0.002215561,0.0005225882,0.0001449079,0.000006378252,0.000007546115,0.002471622],"genre_scores_gemma":[0.997439,0.00003219557,0.001201654,0.0002831424,0.0004484311,0.000006621332,0.000009320382,0.000002984862,0.0005766019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6362928,"threshold_uncertainty_score":0.2892164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06268761454394028,"score_gpt":0.3379554008995432,"score_spread":0.2752677863556029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}