{"id":"W1937800286","doi":"10.1111/cts.12275","title":"Sodium Channel Inhibitors Reduce DMPK mRNA and Protein","year":2015,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario; University of Ottawa","funders":"Institute of Genetics; U.S. Public Health Service; Canadian Institutes of Health Research; University of Ottawa; Spinal Muscular Atrophy Foundation","keywords":"Sodium channel; Messenger RNA; Medicine; Pharmacology; Computational biology; Biology; Chemistry; Bioinformatics; Internal medicine; Sodium; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009153013,0.0002250013,0.0003038499,0.0001817079,0.00009407105,0.0001926541,0.0001317566,0.0001996425,0.001958922],"category_scores_gemma":[0.000137756,0.00006962912,0.0001210672,0.00009139956,0.0001235571,0.0001308192,0.00008795609,0.0003367277,0.0003852843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618823,"about_ca_system_score_gemma":0.0002153692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004509092,"about_ca_topic_score_gemma":0.001416532,"domain_scores_codex":[0.9999186,0.00001339131,0.000007388178,0.00001227691,0.00002716822,0.00002117652],"domain_scores_gemma":[0.999912,0.00001935848,0.0000209505,0.000006142189,0.00001831248,0.00002319128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919593,0.00003412511,0.0001024162,0.00002332792,0.000006392619,0.00001628708,0.00000595373,0.00003508481,0.9970297,0.00006438645,0.00005357172,0.002436781],"study_design_scores_gemma":[0.00002768131,0.0008768402,0.001918986,0.000002874274,0.00001761151,0.0001142,0.00001412877,0.0004181388,0.9949733,0.00002667829,0.001607178,0.000002497643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932866,0.001986919,0.001605229,0.0001209205,0.00004454601,0.00002776551,0.0002022042,0.0001833506,0.002542608],"genre_scores_gemma":[0.9908263,0.001715427,0.002005366,0.00006638922,0.00001772818,0.00002375444,0.0004276388,0.0000294025,0.004888092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958922,"threshold_uncertainty_score":0.006553292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06268761454394028,"score_gpt":0.3379554008995432,"score_spread":0.2752677863556029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}