{"id":"W1938354469","doi":"10.1016/j.ebiom.2015.07.010","title":"Rethinking the Antibiotic Discovery Paradigm","year":2015,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Antibiotics; Drug discovery; Computational biology; Medicine; Data science; Intensive care medicine; Bioinformatics; Biology; Computer science; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1135642,0.001825108,0.003810242,0.007778349,0.007897822,0.02895954,0.009523187,0.01833257,0.004809225],"category_scores_gemma":[0.05581969,0.001294007,0.002768995,0.003711318,0.07088402,0.06474649,0.02105891,0.04818495,0.003862525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01724497,"about_ca_system_score_gemma":0.02604014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003481042,"about_ca_topic_score_gemma":0.003406154,"domain_scores_codex":[0.9302444,0.03383505,0.004333925,0.008220886,0.02040295,0.002962807],"domain_scores_gemma":[0.9094689,0.06118657,0.002684122,0.007111242,0.0132514,0.006297778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001372797,0.0001364728,0.0003741253,0.00134416,0.00008011195,0.0004120581,0.005740638,0.0005065349,0.0008989448,0.8647444,0.0538756,0.07174973],"study_design_scores_gemma":[0.00005758358,0.0001380476,0.0001729564,0.0009831173,0.00002903417,0.0002853394,0.002028371,0.0005451272,0.0004744922,0.5814148,0.4138041,0.00006697379],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002255032,0.06194466,0.03516562,0.864806,0.0121813,0.0001015721,0.0001085142,0.0002032314,0.02323404],"genre_scores_gemma":[0.1514301,0.1527239,0.09549955,0.5415609,0.03701044,0.001208476,0.0004057827,0.0008839954,0.01927682],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1135642,"threshold_uncertainty_score":0.6005918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473312596154086,"score_gpt":0.2416022635949084,"score_spread":0.2168691376333675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}