{"id":"W1939098148","doi":"10.1002/mrd.22413","title":"Post‐ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis","year":2014,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kinexus Bioinformatics Corporation (Canada); University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development","keywords":"Biology; Cell biology; Signal transduction; Oocyte; Kinase; PI3K/AKT/mTOR pathway; Protein kinase A; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571802,0.0002612222,0.000278466,0.0001650362,0.0001426818,0.0003403362,0.0002237116,0.0002208703,0.00104406],"category_scores_gemma":[0.0001547811,0.000133448,0.0002610937,0.000104519,0.000191694,0.0002436151,0.0001573464,0.0003333001,0.0001929775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280047,"about_ca_system_score_gemma":0.0002195992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005380969,"about_ca_topic_score_gemma":0.0008605067,"domain_scores_codex":[0.9998795,0.00001562138,0.0000174942,0.00002827059,0.00002647739,0.00003261058],"domain_scores_gemma":[0.9998751,0.00002287138,0.00004350548,0.00001821057,0.0000144234,0.00002596333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008937634,0.00001154508,0.0002418186,0.00002291914,0.000003833432,0.00003721896,0.00001054666,0.00002139234,0.9988527,0.00004582043,0.00001191186,0.0006509086],"study_design_scores_gemma":[0.000007339022,0.0001781003,0.01626186,0.000004585028,0.00001599316,0.0001937426,0.00003632402,0.0003567114,0.9817108,0.00004818107,0.001182531,0.000003731044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942793,0.002315997,0.002204129,0.00007341296,0.00003347728,0.00002193522,0.0003867595,0.0000462515,0.000638835],"genre_scores_gemma":[0.9957277,0.001052501,0.001425683,0.00004307466,0.000008338292,0.00002869561,0.0003612721,0.00002201213,0.001330844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104406,"threshold_uncertainty_score":0.003492773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627590242986028,"score_gpt":0.2410443361660544,"score_spread":0.2247684337361941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}