{"id":"W1939928011","doi":"10.1023/a:1016253716438","title":"Preclinical Antitumor Activity and Pharmacokinetics of Methyl-2-Benzimidazolecarbamate (FB642)","year":2002,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cancer Care Ontario; Procter and Gamble; Eli Lilly and Company","keywords":"Pharmacokinetics; In vivo; Pharmacology; Medicine; Melanoma; Toxicity; In vitro; Cancer; IC50; Apoptosis; Cancer research; Chemistry; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007824453,0.0006263974,0.0009349755,0.0005811423,0.0003083157,0.0006391603,0.0006594738,0.0007300781,0.001725846],"category_scores_gemma":[0.0008524071,0.0004854887,0.0004584381,0.0004922527,0.0005582857,0.000668849,0.0001608014,0.002125564,0.0004835742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129414,"about_ca_system_score_gemma":0.0008411747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004164966,"about_ca_topic_score_gemma":0.00393391,"domain_scores_codex":[0.9995469,0.0001695805,0.00001957875,0.00005378335,0.00006281,0.000147357],"domain_scores_gemma":[0.9994658,0.0001644738,0.0001226272,0.00006614764,0.00004245238,0.0001385971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1086374,0.02145656,0.004436763,0.0002986601,0.0003244184,0.0005221794,0.000367791,0.007453644,0.7452608,0.001148229,0.00499823,0.1050953],"study_design_scores_gemma":[0.0107084,0.2273513,0.02357583,0.00004183765,0.0006210677,0.001301499,0.0001720291,0.01335475,0.7135808,0.0003870375,0.008833585,0.00007188928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913507,0.003505776,0.001425741,0.0002501847,0.0001000083,0.0001409264,0.0006603021,0.0002119725,0.002354493],"genre_scores_gemma":[0.9957034,0.0009507103,0.0005236784,0.00005353353,0.000057238,0.0001058016,0.0008063351,0.00005130752,0.001747994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004164966,"threshold_uncertainty_score":0.008281469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213157658821065,"score_gpt":0.2863443809432163,"score_spread":0.2542128043550057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}