{"id":"W1939928011","doi":"10.1023/a:1016253716438","title":"Preclinical Antitumor Activity and Pharmacokinetics of Methyl-2-Benzimidazolecarbamate (FB642)","year":2002,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cancer Care Ontario; Procter and Gamble; Eli Lilly and Company","keywords":"Pharmacokinetics; In vivo; Pharmacology; Medicine; Melanoma; Toxicity; In vitro; Cancer; IC50; Apoptosis; Cancer research; Chemistry; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326699,0.0001152104,0.0001217266,0.00003938343,0.00004237526,0.00001517729,0.0001052983,0.00008863282,0.0001067567],"category_scores_gemma":[0.0001864737,0.0001146736,0.00005257747,0.00008524492,0.0002056635,0.00001044856,0.00007452905,0.00008965575,0.00001083465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000532868,"about_ca_system_score_gemma":0.00006057352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002134411,"about_ca_topic_score_gemma":0.000002253621,"domain_scores_codex":[0.9991654,0.00006176982,0.0002244512,0.0002398149,0.0001868975,0.0001216764],"domain_scores_gemma":[0.9994552,0.00003209455,0.0001263471,0.0001551071,0.00006925441,0.0001619583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002274114,0.00005435096,0.001638807,0.00002083239,0.0000341597,5.765765e-7,0.00006314613,0.00004185098,0.9772899,0.0006940215,0.01355416,0.006585461],"study_design_scores_gemma":[0.0006821031,0.00008043733,0.004927444,0.00001639986,0.00001746995,0.000006841681,0.000006579667,0.001312102,0.9714518,0.0007485908,0.02060639,0.0001437961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953849,0.0007053991,0.0002380039,0.001804841,0.000116236,0.000138832,0.00002295455,0.00001323446,0.001575589],"genre_scores_gemma":[0.9947507,0.0002434538,0.00297411,0.0005945219,0.0002662117,0.00000655023,0.00003512934,0.00001262732,0.001116737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007052227,"threshold_uncertainty_score":0.4676255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213157658821065,"score_gpt":0.2863443809432163,"score_spread":0.2542128043550057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}