{"id":"W1940527400","doi":"10.1002/9780470048672.wecb667","title":"Protein Trafficking Diseases: Small Molecule Approaches","year":2008,"lang":"en","type":"other","venue":"Wiley Encyclopedia of Chemical Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Cystic Fibrosis Canada; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Endoplasmic reticulum; Protein folding; Unfolded protein response; Chemical chaperone; Mutant protein; Mutant; Proteasome; Endoplasmic-reticulum-associated protein degradation; Cell biology; Biology; Calnexin; Transport protein; Protein aggregation; Protein quality; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005806299,0.0004274315,0.001021948,0.0002712648,0.00001854695,0.000003651439,0.0003908866,0.000939743,0.001148643],"category_scores_gemma":[0.0004627642,0.0003573901,0.0002979549,0.0002598372,0.0007120876,0.0000124566,0.0001822743,0.0005585222,0.00009075074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007017925,"about_ca_system_score_gemma":0.0003303143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266429,"about_ca_topic_score_gemma":0.000006296644,"domain_scores_codex":[0.9979162,0.00008891171,0.0004310839,0.0007119473,0.0002764509,0.0005754346],"domain_scores_gemma":[0.9987726,0.00006945362,0.000234262,0.0005598202,0.00005583312,0.0003080065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001656037,0.005474044,0.01523749,0.006836288,0.002095925,0.0008759936,0.0006740097,9.202316e-7,0.1371728,0.001029069,0.6874399,0.1415075],"study_design_scores_gemma":[0.003357514,0.0006497059,0.00009304631,0.00132864,0.0002960249,0.0001106624,0.00005385243,0.00004665833,0.0170478,0.0001599176,0.9758197,0.001036469],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.05703095,0.0183739,0.00008950193,0.0002835451,0.0001291883,0.002098408,0.0002024983,0.0003309298,0.921461],"genre_scores_gemma":[0.200382,0.02742887,0.01266569,0.0006906689,0.005900532,0.002228157,0.007756412,0.003564985,0.7393826],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2883798,"threshold_uncertainty_score":0.9998878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0268589113532705,"score_gpt":0.2625777044123123,"score_spread":0.2357187930590418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}