{"id":"W1940527400","doi":"10.1002/9780470048672.wecb667","title":"Protein Trafficking Diseases: Small Molecule Approaches","year":2008,"lang":"en","type":"other","venue":"Wiley Encyclopedia of Chemical Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Cystic Fibrosis Canada; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Endoplasmic reticulum; Protein folding; Unfolded protein response; Chemical chaperone; Mutant protein; Mutant; Proteasome; Endoplasmic-reticulum-associated protein degradation; Cell biology; Biology; Calnexin; Transport protein; Protein aggregation; Protein quality; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285158,0.0006533664,0.0006023283,0.0009381258,0.0002729415,0.0007315766,0.0004265385,0.0006229791,0.00693105],"category_scores_gemma":[0.0001367669,0.0001592007,0.000353996,0.0006215326,0.0002570241,0.0005441909,0.000642808,0.001040096,0.004715707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004817916,"about_ca_system_score_gemma":0.0002097399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002669417,"about_ca_topic_score_gemma":0.0004425308,"domain_scores_codex":[0.999907,0.00001462287,0.000007878471,0.00002185221,0.00003160384,0.00001706266],"domain_scores_gemma":[0.9999543,0.000009420878,0.00000718608,0.00000523187,0.00001323887,0.00001060927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003064057,0.0005424924,0.0002297255,0.004379427,0.0001020462,0.00132389,0.0001173684,0.001140737,0.2840474,0.03445225,0.03666012,0.6366982],"study_design_scores_gemma":[0.00008586256,0.0004494404,0.000578706,0.0002999368,0.00006857845,0.001594221,0.00002745406,0.0005709209,0.06175005,0.005839094,0.9287076,0.00002821441],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02275307,0.8297995,0.03052359,0.004110029,0.002948772,0.0003736913,0.00125011,0.0009367303,0.1073045],"genre_scores_gemma":[0.1289262,0.772681,0.01747738,0.002700167,0.0008337937,0.0004845501,0.001474199,0.00009650012,0.07532623],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00693105,"threshold_uncertainty_score":0.02318662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0268589113532705,"score_gpt":0.2625777044123123,"score_spread":0.2357187930590418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}