{"id":"W1940693634","doi":"10.1073/pnas.1508836112","title":"Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Government of Canada; Human Frontier Science Program; National Institutes of Health; Ministry of Education, India; Ministry of Earth Sciences","keywords":"G protein-coupled receptor; Cell biology; G protein-coupled receptor kinase; Biology; Arrestin; Receptor; Signal transduction; Protein kinase A; Kinase; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334632,0.0002195498,0.0003360537,0.0001079884,0.0001518757,0.0003822351,0.00017807,0.0001758252,0.001097226],"category_scores_gemma":[0.00009564137,0.0001645845,0.00027204,0.000103032,0.0001606895,0.0002127358,0.0001899114,0.0005343857,0.0004252607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000296264,"about_ca_system_score_gemma":0.0001677578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004282064,"about_ca_topic_score_gemma":0.0005638478,"domain_scores_codex":[0.9998387,0.00001705622,0.0000136361,0.00004044963,0.00003410485,0.00005613155],"domain_scores_gemma":[0.9999155,0.00001359971,0.00002819985,0.00001119952,0.00001276494,0.00001876686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000599338,0.000009508595,0.0001047814,0.00001494807,0.000002591567,0.00001769036,0.000006425756,0.00003589646,0.9994119,0.00006296073,0.00001899165,0.0002543255],"study_design_scores_gemma":[0.00001042884,0.00009905751,0.01079516,0.000004817391,0.00001144563,0.000174064,0.00003415392,0.001823931,0.9856901,0.00006746051,0.001281902,0.000007590509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959648,0.0008969962,0.00187022,0.00006833977,0.00001269535,0.0000131227,0.0002879188,0.00004988985,0.0008361287],"genre_scores_gemma":[0.9968863,0.0005675635,0.0007890679,0.00004090748,0.000007189301,0.00002787682,0.0004236384,0.00001766758,0.001239887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001097226,"threshold_uncertainty_score":0.003670633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04175553390792171,"score_gpt":0.2983438529039576,"score_spread":0.2565883189960359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}