{"id":"W1941073507","doi":"10.3390/toxins7104054","title":"The Effects of Shiga Toxin 1, 2 and Their Subunits on Cytokine and Chemokine Expression by Human Macrophage-Like THP-1 Cells","year":2015,"lang":"en","type":"article","venue":"Toxins","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Glycomics Centre","keywords":"Shiga toxin; Chemokine; Macrophage; Microbiology; Cytokine; Biology; THP1 cell line; STX2; Cytotoxic T cell; Innate immune system; Immunology; Cell culture; Immune system; In vitro; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003131181,0.0002489378,0.0002072575,0.0001084051,0.0001077411,0.000211905,0.00007759743,0.0002220722,0.0007687932],"category_scores_gemma":[0.0001902453,0.0001340017,0.0002541898,0.0001430472,0.000155612,0.000159167,0.0001170868,0.0003335264,0.0001963376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001241247,"about_ca_system_score_gemma":0.0001484678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003803081,"about_ca_topic_score_gemma":0.0004948938,"domain_scores_codex":[0.9998056,0.00007309545,0.00002109309,0.00001855928,0.00002719499,0.000054511],"domain_scores_gemma":[0.9998727,0.0000565529,0.00001608652,0.00001389981,0.00002012064,0.00002066375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009356054,0.00007344127,0.0004771537,0.0000642942,0.000008662278,0.00008988487,0.00005988639,0.00008397333,0.997346,0.00003169786,0.00004106701,0.0007883232],"study_design_scores_gemma":[0.0001109697,0.004041763,0.03057494,0.00001960878,0.00003343955,0.0003254095,0.0001643656,0.001152081,0.9616721,0.00005488588,0.00183678,0.00001365237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973885,0.00150453,0.0003056281,0.0000522894,0.0000273583,0.00001591508,0.0002553061,0.000004625028,0.0004459057],"genre_scores_gemma":[0.9960846,0.001210703,0.00094898,0.00008951582,0.00003167154,0.00005778038,0.0005432291,0.00000395573,0.001029487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007687932,"threshold_uncertainty_score":0.002571821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009749454334797875,"score_gpt":0.2520262983264075,"score_spread":0.2422768439916096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}