{"id":"W1941073507","doi":"10.3390/toxins7104054","title":"The Effects of Shiga Toxin 1, 2 and Their Subunits on Cytokine and Chemokine Expression by Human Macrophage-Like THP-1 Cells","year":2015,"lang":"en","type":"article","venue":"Toxins","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Glycomics Centre","keywords":"Shiga toxin; Chemokine; Macrophage; Microbiology; Cytokine; Biology; THP1 cell line; STX2; Cytotoxic T cell; Innate immune system; Immunology; Cell culture; Immune system; In vitro; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285163,0.0001552841,0.0001525264,0.00001817221,0.0001501964,0.00002344791,0.0001524896,0.00008600362,0.000001584398],"category_scores_gemma":[0.0001686507,0.00009496979,0.00002641797,0.00005968387,0.0002257768,0.000003393845,0.0002619119,0.0001125609,9.763374e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009147695,"about_ca_system_score_gemma":0.00002192388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002008429,"about_ca_topic_score_gemma":0.00003264361,"domain_scores_codex":[0.999183,0.00009956783,0.0001189511,0.0002364198,0.0001381422,0.0002238996],"domain_scores_gemma":[0.9993757,0.00008965225,0.0000569613,0.0002876819,0.00006793591,0.000122063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008742621,0.00005753006,0.0002896424,0.00004644062,0.0000301925,0.000001928711,0.0001905904,6.436037e-7,0.9853342,0.00001534693,0.01297751,0.0009685903],"study_design_scores_gemma":[0.0007666409,0.0008430281,0.0009373915,0.00003070225,0.00000569332,0.000001560668,0.0001266735,0.000009007623,0.9705288,0.00003908038,0.02660943,0.0001019814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938944,0.00465302,0.0000238591,0.000136505,0.0000613466,0.000236059,0.00002616464,0.000008512734,0.000960158],"genre_scores_gemma":[0.9969772,0.001130671,0.00005257266,0.0001210153,0.00007265103,0.00002560128,0.00001692287,0.00001801899,0.001585387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01480535,"threshold_uncertainty_score":0.3872755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009749454334797875,"score_gpt":0.2520262983264075,"score_spread":0.2422768439916096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}