{"id":"W1941145541","doi":"10.1093/nar/gkv679","title":"Nucleic acid-binding specificity of human FUS protein","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Colorado Boulder; University of Toronto; Howard Hughes Medical Institute","keywords":"Nucleic acid; Biology; RNA; DNA; Nucleic acid structure; Binding site; RNA-binding protein; Biochemistry; Binding selectivity; Molecular biology; Plasma protein binding; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002503692,0.0001719375,0.0002424131,0.0002521921,0.0002645417,0.00007580527,0.000760141,0.0002336153,0.0001431971],"category_scores_gemma":[0.0007043621,0.000160025,0.0001089569,0.000460422,0.0004605969,0.00001293671,0.0006262973,0.0005257571,0.0001710841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009821515,"about_ca_system_score_gemma":0.0002790232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001762805,"about_ca_topic_score_gemma":0.00004648971,"domain_scores_codex":[0.9967853,0.0003803571,0.0003269576,0.0005116405,0.001144001,0.0008517439],"domain_scores_gemma":[0.9981214,0.00001950258,0.00006896721,0.0007698704,0.0005721966,0.0004480748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001976055,0.0001199708,0.00353645,0.0000441811,0.00003268617,0.00001822266,0.0001039014,0.000002462099,0.9869649,0.0006129169,0.006379679,0.001987029],"study_design_scores_gemma":[0.0009851076,0.001487848,0.001474796,0.00005158181,0.000003075384,0.000009807204,0.0009034309,0.0001035855,0.9818192,0.0004128403,0.01254067,0.0002080381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821057,0.0002765155,0.00007919046,0.0001952664,0.00004101065,0.0005008314,0.00001686204,0.000019966,0.01676465],"genre_scores_gemma":[0.9899189,0.00002878012,0.000559033,0.00001478687,0.0003118936,0.00003989353,0.00004532641,0.00004878048,0.009032542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007813258,"threshold_uncertainty_score":0.652563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0831361595290062,"score_gpt":0.3700296325200453,"score_spread":0.2868934729910391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}