{"id":"W1941304436","doi":"10.4049/jimmunol.164.9.4513","title":"Evidence of Selective Processing of Immunodominant Epitopes in Virally Infected Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Medical Council of Canada","funders":"National Cancer Institute; Medical Research Council","keywords":"Epitope; Antigen processing; Immunodominance; MHC class I; Biology; Transporter associated with antigen processing; Antigen presentation; Proteases; Cytotoxic T cell; CTL*; Proteasome; Virology; Vesicular stomatitis virus; Antigen; Protease; Major histocompatibility complex; Virus; Cell biology; CD8; Genetics; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223152,0.0003207245,0.0002149945,0.0002470076,0.0002341238,0.000525397,0.0002550546,0.0005898527,0.001575871],"category_scores_gemma":[0.0004834455,0.0001923353,0.0002285241,0.0001953766,0.0002866958,0.0003231455,0.0003205445,0.0006963006,0.001296336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227477,"about_ca_system_score_gemma":0.000165841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599657,"about_ca_topic_score_gemma":0.0001906859,"domain_scores_codex":[0.999632,0.00005519048,0.00004306885,0.00006244652,0.0001304098,0.00007690185],"domain_scores_gemma":[0.9993132,0.0002422856,0.00008264813,0.0001670444,0.00009266387,0.0001020783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000502749,0.00001252852,0.0004045529,0.00002471361,0.000003580065,0.00009222012,0.0000200524,0.00001852267,0.9987572,0.0001681218,0.00001914419,0.0004290421],"study_design_scores_gemma":[0.00001683374,0.0002397503,0.00961266,0.000008227559,0.00001332415,0.002880762,0.00005056568,0.0006964494,0.9846947,0.000191592,0.001589568,0.000005685779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867166,0.001806586,0.006994993,0.0001093302,0.00004441834,0.00002399626,0.0005330954,0.00009577986,0.003675112],"genre_scores_gemma":[0.9941327,0.0007137672,0.00246332,0.00005149392,0.00001570647,0.0000293712,0.001289933,0.00002247836,0.001281226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001575871,"threshold_uncertainty_score":0.005271792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184328483462638,"score_gpt":0.2516347711254016,"score_spread":0.2397914862907752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}