{"id":"W1941336070","doi":"10.1186/s13072-015-0023-7","title":"Strategies for precision modulation of gene expression by epigenome editing: an overview","year":2015,"lang":"en","type":"review","venue":"Epigenetics & Chromatin","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Genome editing; Epigenome; Biology; Effector; CRISPR; Computational biology; Transcription activator-like effector nuclease; Zinc finger nuclease; Cas9; Epigenetics; Genetics; Genomics; Genome; DNA methylation; Gene; Gene expression; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004962906,0.0005163422,0.001059678,0.00009782313,0.00006830649,0.00005154704,0.000461653,0.000581695,0.0000146085],"category_scores_gemma":[0.00007720097,0.0004828871,0.0003400772,0.0001313001,0.00004990099,0.000009198134,0.0001271793,0.0001233107,0.000004051662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004045036,"about_ca_system_score_gemma":0.0003087714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006378206,"about_ca_topic_score_gemma":0.000004674554,"domain_scores_codex":[0.9975858,0.0001434688,0.0009507412,0.0006520902,0.0003097506,0.0003581222],"domain_scores_gemma":[0.9981855,0.00004087135,0.0005503055,0.0008262328,0.000222314,0.0001747551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001898049,0.0001849876,0.000003491269,0.01210341,0.0001452979,9.278154e-7,0.0001597343,0.002157121,0.3477517,0.00004298829,0.006249054,0.6311823],"study_design_scores_gemma":[0.0003340988,0.000620839,0.000007415188,0.001874346,0.0002232092,0.000006171728,0.00007129065,0.0003550681,0.05051241,0.0001484815,0.9452822,0.0005644226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008901821,0.9287115,0.06832878,0.000002401387,0.0003281056,0.001086515,0.0005269151,0.00002222392,0.0001034159],"genre_scores_gemma":[0.001044895,0.9688873,0.02410641,0.0000060022,0.0007938982,0.0001981306,0.00466718,0.0001403302,0.0001558444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9390332,"threshold_uncertainty_score":0.9997623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05798794850904982,"score_gpt":0.3947767803478088,"score_spread":0.336788831838759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}