{"id":"W1941925635","doi":"10.1158/1538-7445.sabcs14-ot3-1-10","title":"Abstract OT3-1-10: HERmione: A Phase 2, randomized, open label trial comparing MM-302 plus trastuzumab with physician's choice of chemotherapy plus trastuzumab, in anthracycline naive HER2-positive, locally advanced/metastatic breast cancer, previously treated with pe","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Pertuzumab; Trastuzumab; Medicine; Vinorelbine; Capecitabine; Internal medicine; Anthracycline; Oncology; Metastatic breast cancer; Taxane; Trastuzumab emtansine; Chemotherapy; Breast cancer; Lapatinib; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001629384,0.002066728,0.001726363,0.0004258482,0.0003282943,0.00103004,0.001080488,0.001714653,0.009246685],"category_scores_gemma":[0.001362493,0.0005498878,0.001367095,0.0002949678,0.001220269,0.001192393,0.0004283858,0.003380662,0.001291625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007649664,"about_ca_system_score_gemma":0.001260565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008657549,"about_ca_topic_score_gemma":0.002335575,"domain_scores_codex":[0.9996124,0.0001958363,0.00001788085,0.00008514317,0.0000253883,0.00006335068],"domain_scores_gemma":[0.9993384,0.000174965,0.0001449172,0.00004054693,0.0000299468,0.0002712786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9674726,0.01221422,0.0004390563,0.0004531739,0.0003684225,0.00005145994,0.00005580546,0.0004567963,0.00443962,0.0002256466,0.001586953,0.01223637],"study_design_scores_gemma":[0.9218074,0.07573878,0.0008474126,0.00002536627,0.0001386985,0.00002458161,0.00001563035,0.0003324834,0.0003506778,0.0001118948,0.0005959689,0.00001117923],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833174,0.002354669,0.0005939234,0.000986818,0.0006084638,0.005672318,0.001958388,0.0001974909,0.004310439],"genre_scores_gemma":[0.9726054,0.002039176,0.002412477,0.001947813,0.000712494,0.008459631,0.00282411,0.0000392768,0.008959632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009246685,"threshold_uncertainty_score":0.0309332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1442824280555972,"score_gpt":0.4836444026667105,"score_spread":0.3393619746111133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}