{"id":"W1941936676","doi":"10.1111/j.1742-4658.2007.06177.x","title":"Effects of the G376E and G157D mutations on the stability of yeast enolase – a model for human muscle enolase deficiency","year":2007,"lang":"en","type":"article","venue":"FEBS Journal","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Enolase; Protein subunit; Biochemistry; Yeast; Glycine; Biology; Molecular biology; Enzyme; Mutant; Isozyme; Trypsin; Chemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003647449,0.0000668534,0.00007307801,0.00002021567,0.0001998388,0.00001088252,0.0001289716,0.00004726937,0.000004947749],"category_scores_gemma":[0.0001895066,0.00003823986,0.00009363429,0.00004442594,0.0001099979,0.000002947881,0.00003955884,0.00009033985,1.452508e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006891334,"about_ca_system_score_gemma":0.00005157345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007993264,"about_ca_topic_score_gemma":0.00003092765,"domain_scores_codex":[0.9994725,0.00003828673,0.0001710576,0.00009676079,0.00009547019,0.0001259345],"domain_scores_gemma":[0.9995408,0.00004408546,0.0001291444,0.0001568091,0.00008988901,0.00003927727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005054979,0.0001415589,0.0004121918,0.00003183386,0.00001105491,5.334682e-7,0.0002680594,0.0001041176,0.9970924,0.0006944982,0.00004368169,0.00114958],"study_design_scores_gemma":[0.0005969419,0.0004752101,0.01855362,0.00003436704,0.00002680188,0.00001113013,0.0002199233,0.0005300587,0.978034,0.001307497,0.0001447384,0.00006573833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908058,0.0002107658,0.008408424,0.000081453,0.00003572702,0.000243613,0.00002738608,0.000001259676,0.000185594],"genre_scores_gemma":[0.9995595,0.00001031994,0.0002650673,0.00005908978,0.00005305672,0.000006928273,0.000001913227,0.000006991992,0.00003714194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01905837,"threshold_uncertainty_score":0.1559376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674184628377626,"score_gpt":0.2621114597762401,"score_spread":0.2453696134924639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}