{"id":"W1941960325","doi":"10.1002/path.4633","title":"Dual loss of the <scp>SWI</scp>/<scp>SNF</scp> complex <scp>ATPases SMARCA4</scp>/<scp>BRG1</scp> and <scp>SMARCA2</scp>/<scp>BRM</scp> is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type","year":2015,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Terry Fox Foundation; Rivkin Center for Ovarian Cancer","keywords":"SMARCA4; Cancer research; Biology; Trichostatin A; Histone deacetylase; Chromatin remodeling; Chromatin; Histone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939029,0.000253685,0.0002999227,0.0006986414,0.00016459,0.0002521475,0.0001927566,0.0002958795,0.001736402],"category_scores_gemma":[0.0003177011,0.0001683569,0.0002503018,0.0002923286,0.0003914002,0.0001559363,0.0002476479,0.0002998075,0.0002726309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837178,"about_ca_system_score_gemma":0.0001338663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028041,"about_ca_topic_score_gemma":0.001160547,"domain_scores_codex":[0.9997264,0.00003107104,0.00002964952,0.00007079661,0.00009302756,0.00004905743],"domain_scores_gemma":[0.9997979,0.00003404753,0.00006362888,0.00002662472,0.00002899309,0.00004884126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002098039,0.00001393209,0.01581249,0.00004717027,0.00003553451,0.0002690285,0.00002779659,0.00004928583,0.9793596,0.00009480606,0.00007061835,0.004010024],"study_design_scores_gemma":[0.00004279429,0.0006801024,0.3257078,0.00001556504,0.0001243214,0.0125729,0.0001324911,0.001386743,0.6512694,0.0002143933,0.007839993,0.00001362406],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967752,0.001273931,0.000837677,0.00003015081,0.00001028176,0.000008064508,0.0002284842,0.00002776597,0.0008083473],"genre_scores_gemma":[0.9982286,0.0002755995,0.0003152239,0.0000198177,0.000004309988,0.000009458019,0.0003151001,0.000006291873,0.0008255665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001736402,"threshold_uncertainty_score":0.00580883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03324258209698763,"score_gpt":0.2473025126320964,"score_spread":0.2140599305351087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}