{"id":"W1941960325","doi":"10.1002/path.4633","title":"Dual loss of the <scp>SWI</scp>/<scp>SNF</scp> complex <scp>ATPases SMARCA4</scp>/<scp>BRG1</scp> and <scp>SMARCA2</scp>/<scp>BRM</scp> is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type","year":2015,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Terry Fox Foundation; Rivkin Center for Ovarian Cancer","keywords":"SMARCA4; Cancer research; Biology; Trichostatin A; Histone deacetylase; Chromatin remodeling; Chromatin; Histone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.002995528,0.00130375,0.001990284,0.0003741833,0.0006772432,0.0001420011,0.001739545,0.001208758,0.000003770581],"category_scores_gemma":[0.004749423,0.0008990668,0.0009232793,0.000755247,0.00232074,0.00007143222,0.001365182,0.001545159,0.00001934995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759038,"about_ca_system_score_gemma":0.0009996608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001457294,"about_ca_topic_score_gemma":0.0001201785,"domain_scores_codex":[0.9919738,0.00166692,0.00216333,0.001269907,0.001150301,0.001775778],"domain_scores_gemma":[0.9879721,0.004804211,0.002751808,0.001739471,0.002047095,0.0006852793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006235,0.000768864,0.01894787,0.0005706218,0.0008017034,0.0002773141,0.01278871,0.0007319009,0.8254809,0.0002214338,0.1385963,0.0007137741],"study_design_scores_gemma":[0.01137469,0.004623847,0.05560659,0.0004864401,0.002006094,0.01006914,0.03172298,0.001500229,0.7765208,0.003099359,0.102763,0.0002268083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768945,0.01549998,0.0006217805,0.0002691118,0.001523975,0.001239111,0.0007388085,0.0000438796,0.00316885],"genre_scores_gemma":[0.9881111,0.00370006,0.001369276,0.001163632,0.001481145,0.00003126265,0.0001052701,0.000232755,0.00380554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04896007,"threshold_uncertainty_score":0.9999714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03324258209698763,"score_gpt":0.2473025126320964,"score_spread":0.2140599305351087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}