{"id":"W1942361731","doi":"10.4049/jimmunol.1103717","title":"Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Immunogenicity; Tropism; Biology; Virology; Recombinant DNA; Serotype; Viral vector; T cell; Vaccination; Adenoviridae; CD8; Immune system; Immunology; Virus; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002748506,0.0004047692,0.0002430126,0.0001528373,0.00006113896,0.0003107568,0.00008714485,0.000226383,0.0006143727],"category_scores_gemma":[0.0001627695,0.00009276991,0.0004349186,0.00008294798,0.0001598854,0.0001468207,0.0001319027,0.0004436446,0.0001630823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001758763,"about_ca_system_score_gemma":0.0001304221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001398058,"about_ca_topic_score_gemma":0.000190914,"domain_scores_codex":[0.9997957,0.00004560578,0.00003270283,0.00003405902,0.00004765845,0.00004426714],"domain_scores_gemma":[0.9998721,0.00004014507,0.00003315696,0.00002121819,0.00001478406,0.00001867014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001930515,0.00003056293,0.0008544211,0.00005177169,0.000008614537,0.00004427769,0.0000135139,0.00008642883,0.9962606,0.00004509543,0.00001299203,0.002398662],"study_design_scores_gemma":[0.0000153216,0.00138933,0.01254554,0.0000185664,0.00005787144,0.0003718144,0.00005501059,0.0005682064,0.9832697,0.0000654978,0.001636737,0.000006407547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995349,0.002156803,0.00136444,0.0000338881,0.00002844182,0.00001651073,0.0001047705,0.00002511033,0.0009211364],"genre_scores_gemma":[0.997127,0.0009205326,0.001015265,0.0000336964,0.000007397882,0.00001257142,0.0001462167,0.000004908835,0.0007324481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006143727,"threshold_uncertainty_score":0.002055287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059835176264788,"score_gpt":0.2739177717176115,"score_spread":0.2533194199549636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}