{"id":"W1942725639","doi":"10.1128/jvi.01725-15","title":"Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Raltegravir; Integrase; Infectivity; Biology; Virology; Drug resistance; Mutation; Viral replication; Integrase inhibitor; Resistance mutation; Molecular biology; Viral load; Genetics; Human immunodeficiency virus (HIV); Virus; Antiretroviral therapy; Reverse transcriptase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001968728,0.0002595682,0.0003515061,0.0001032747,0.0001667691,0.0004500806,0.0002793281,0.0002303874,0.002419281],"category_scores_gemma":[0.0001425869,0.0001005428,0.0002161253,0.00009754382,0.0003731437,0.0001538996,0.000198704,0.000586828,0.0006378395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004905365,"about_ca_system_score_gemma":0.0002340568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009088239,"about_ca_topic_score_gemma":0.001370542,"domain_scores_codex":[0.999804,0.00002714116,0.00002202717,0.00004967385,0.00005794494,0.00003930608],"domain_scores_gemma":[0.9998647,0.00002824581,0.00004139873,0.00002305022,0.00001139338,0.00003114159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001471539,0.00006526477,0.0005426087,0.00002567828,0.000007194405,0.00005189683,0.00001064091,0.0000882794,0.9976502,0.00006762048,0.00004242985,0.001301129],"study_design_scores_gemma":[0.00003433194,0.0006140286,0.006656911,0.000009081533,0.00001503486,0.0004648485,0.00003477588,0.001029505,0.9888566,0.00002763441,0.002250011,0.000007150106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975991,0.0002650645,0.0006075882,0.00003542343,0.0000149135,0.00001505434,0.000257761,0.0000306433,0.001174456],"genre_scores_gemma":[0.9964348,0.0001374287,0.001329839,0.000053398,0.000007267175,0.0000122211,0.000735457,0.0000258444,0.001263693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002419281,"threshold_uncertainty_score":0.008093357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0526299831356294,"score_gpt":0.2797993706994572,"score_spread":0.2271693875638278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}