{"id":"W1942805176","doi":"10.4049/jimmunol.1004111","title":"Neuroinflammation and Endoplasmic Reticulum Stress Are Coregulated by Crocin To Prevent Demyelination and Neurodegeneration","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Endoplasmic reticulum; Unfolded protein response; Neuroinflammation; Neurodegeneration; Experimental autoimmune encephalomyelitis; Crocin; Immunology; Cell biology; Biology; Multiple sclerosis; Pharmacology; Medicine; Internal medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323019,0.000473007,0.0006603203,0.0003186648,0.0001638512,0.00024217,0.0002764843,0.0004067349,0.001212924],"category_scores_gemma":[0.0001978,0.0001556697,0.0003185658,0.0001699636,0.0003473898,0.0003052875,0.0002038948,0.0008626254,0.000190383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197699,"about_ca_system_score_gemma":0.0004115602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008551429,"about_ca_topic_score_gemma":0.001907651,"domain_scores_codex":[0.9998282,0.00002780717,0.00001881662,0.00002789924,0.00003242931,0.00006478811],"domain_scores_gemma":[0.9998503,0.0000109214,0.00004034561,0.00001352395,0.00002562831,0.00005931932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001480864,0.0003440857,0.0001283061,0.0000895786,0.00001079683,0.00005070453,0.0000160503,0.00003587081,0.9950936,0.00006437409,0.00004465923,0.002641162],"study_design_scores_gemma":[0.0003697065,0.005421977,0.009646269,0.0000322069,0.00006991201,0.000274139,0.00004346457,0.0006723202,0.981555,0.00007480083,0.001829226,0.00001096805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947525,0.002238294,0.001570205,0.0001489267,0.00006063554,0.00009225275,0.0001637516,0.0001323627,0.0008410984],"genre_scores_gemma":[0.9949843,0.001305947,0.001436258,0.000101696,0.00002452801,0.0001028655,0.0003535864,0.00001861489,0.001672147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212924,"threshold_uncertainty_score":0.004057646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006755746852670624,"score_gpt":0.2038272443769832,"score_spread":0.1970714975243125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}