{"id":"W1942978027","doi":"10.5376/ijmms.2013.03.0007","title":"Ku Haploinsuffiency Causes a Lymphoproliferative Disorder of Immature T-cell Precursors due to Ikaros Malfunction","year":2013,"lang":"en","type":"article","venue":"International Journal of Molecular Medical Science","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Wellcome Trust","keywords":"Ku80; Ku70; Interleukin-7 receptor; Biology; Pathogenesis; CD8; Cancer research; Gene; Immunology; Cell biology; DNA repair; Genetics; T cell; Transcription factor; DNA-binding protein; Antigen; Immune system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007329159,0.0005115711,0.0002075909,0.0004044564,0.0002993628,0.0001884428,0.0002455972,0.0003864379,0.001357323],"category_scores_gemma":[0.0003337834,0.0001970288,0.0001291855,0.0002012884,0.0003992034,0.0001478738,0.0002849159,0.0004691343,0.0002508206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648416,"about_ca_system_score_gemma":0.0001265957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002949076,"about_ca_topic_score_gemma":0.0003496004,"domain_scores_codex":[0.9998914,0.00002089719,0.00001924876,0.00002475627,0.0000208977,0.00002291339],"domain_scores_gemma":[0.9997271,0.00008217132,0.00006559033,0.00002277283,0.00001197466,0.00009056456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000744948,0.00009329375,0.008720454,0.0001117518,0.0000398855,0.08215815,0.0002080975,0.0003311805,0.8986248,0.000773325,0.0004354895,0.007758581],"study_design_scores_gemma":[0.0004172044,0.001595336,0.1548311,0.00004816735,0.000227579,0.4180433,0.0005953324,0.002682668,0.4109507,0.001736168,0.008785974,0.00008663302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979162,0.0002723875,0.0006889055,0.00006980296,0.00001885026,0.00001757634,0.000132655,0.00008877349,0.0007949785],"genre_scores_gemma":[0.9991353,0.0001146313,0.0002816665,0.00002252392,0.000007980684,0.000006704764,0.00008444059,0.0000125893,0.0003340375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357323,"threshold_uncertainty_score":0.004540682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006565501358398355,"score_gpt":0.2942075633292231,"score_spread":0.2876420619708248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}