{"id":"W1943135484","doi":"10.1002/mus.23904","title":"SMA valiant trial: A prospective, double‐blind, placebo‐controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy","year":2013,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke","keywords":"Spinal muscular atrophy; SMA*; Medicine; Placebo; Ambulatory; Valproic Acid; Isometric exercise; Physical therapy; Clinical trial; Internal medicine; Anesthesia; Epilepsy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00061977,0.0003847942,0.001152698,0.0003654503,0.00007546251,0.00004319381,0.0002525907,0.0001922404,0.0002470728],"category_scores_gemma":[0.000132843,0.0002813827,0.0006100829,0.0006519948,0.0001961115,0.000133662,0.00009680259,0.0005068132,0.0000564609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038919,"about_ca_system_score_gemma":0.0004329409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007706764,"about_ca_topic_score_gemma":0.00009942798,"domain_scores_codex":[0.9964613,0.0002476357,0.0008073082,0.0007430267,0.001064486,0.0006762939],"domain_scores_gemma":[0.998224,0.00005168332,0.000248211,0.0008101471,0.0003569186,0.0003090875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9845707,0.00176237,0.0009407983,0.0002683248,0.0003296397,0.0001194441,0.0003464043,0.00002147668,0.007394064,0.00005790775,0.00008787838,0.004100989],"study_design_scores_gemma":[0.9646133,0.0135911,0.01716842,0.0002783682,0.0002282275,0.00001807241,0.0003828761,0.0003796649,0.002759633,0.00005568052,0.0002363414,0.0002883379],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768623,0.0008179375,0.00007083231,0.0003920912,0.0001965211,0.02039988,0.000002715009,0.00005714948,0.001200542],"genre_scores_gemma":[0.9948428,0.00007568341,0.0004516171,0.0000707648,0.0002800768,0.003740236,0.00001286894,0.0000817911,0.0004441506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01995742,"threshold_uncertainty_score":0.9999638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230891315939462,"score_gpt":0.2891402743874028,"score_spread":0.2660511427934566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}