{"id":"W1944128383","doi":"10.1111/j.1365-2958.2010.07229.x","title":"Localization and induction of the A2 virulence factor in <i>Leishmania</i>: evidence that A2 is a stress response protein","year":2010,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Phagolysosome; Biology; Leishmania; Leishmania major; Amastigote; Heat shock protein; Leishmania donovani; Kinetoplastida; Endoplasmic reticulum; Visceral leishmaniasis; Vector (molecular biology); Leishmaniasis; Cell biology; Microbiology; Immunology; Gene; Parasite hosting; Recombinant DNA; Phagosome; Phagocytosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000261,0.0002846137,0.0001239174,0.0002244564,0.0001803252,0.0003127443,0.0001226421,0.0002867808,0.0009964462],"category_scores_gemma":[0.0001028463,0.0001287039,0.0002316594,0.0001443223,0.0002153043,0.0001718317,0.0002309606,0.0003659701,0.0004944248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140718,"about_ca_system_score_gemma":0.0001443061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000741094,"about_ca_topic_score_gemma":0.0005871044,"domain_scores_codex":[0.9999125,0.00001446063,0.000006410656,0.00002032379,0.00001803439,0.00002825505],"domain_scores_gemma":[0.9998744,0.00001532748,0.00002924319,0.000016157,0.0000259215,0.00003907663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003867572,0.000004683668,0.00006658958,0.00001074309,0.000001160656,0.0000223969,0.00000395094,0.000003072315,0.999733,0.00001714156,0.000009400155,0.00008905904],"study_design_scores_gemma":[0.00001938074,0.0002994926,0.01923618,0.000007236149,0.00001317534,0.0008503591,0.00005220283,0.0003221893,0.9764296,0.00005293234,0.002711617,0.000005703438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962909,0.0009328676,0.00132689,0.0001016148,0.00002036052,0.00001165627,0.0003645648,0.00003852518,0.0009126183],"genre_scores_gemma":[0.9932973,0.0004470022,0.001587053,0.00009497144,0.00001870295,0.00002193911,0.001523947,0.00003666013,0.002972445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009964462,"threshold_uncertainty_score":0.003333449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02618612565451882,"score_gpt":0.2922750156866021,"score_spread":0.2660888900320832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}