{"id":"W1944300754","doi":"10.4049/jimmunol.181.1.776","title":"Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; York University; Cancer Research Institute; Ludwig Institute for Cancer Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Emerald Foundation; Burroughs Wellcome Fund","keywords":"Imiquimod; TLR7; Medicine; Adjuvant; Immunogenicity; Immunology; Peripheral blood mononuclear cell; Immune system; Melanoma; Cancer research; Innate immune system; Biology; Toll-like receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261988,0.0001993796,0.0002894105,0.00008122539,0.0001189892,0.00009478032,0.00007184944,0.0001417341,0.0005989822],"category_scores_gemma":[0.00008609945,0.00007175652,0.00016573,0.00004558337,0.00009756335,0.0001075678,0.0001024557,0.0002912018,0.0001533301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001444,"about_ca_system_score_gemma":0.0001639148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002173396,"about_ca_topic_score_gemma":0.0003810377,"domain_scores_codex":[0.9999495,0.0000116451,0.00000348913,0.00001080642,0.000009232946,0.00001545963],"domain_scores_gemma":[0.9999715,0.000005928559,0.000006039986,0.000004048007,0.00000347524,0.000009034311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.002362652,0.001643031,0.005484063,0.0001421851,0.00003442144,0.0002288049,0.0001018484,0.0004209696,0.9593318,0.00006033177,0.0002746441,0.02991518],"study_design_scores_gemma":[0.001387572,0.1734706,0.07354477,0.00005598516,0.0003337359,0.00339129,0.0002506485,0.004118713,0.7299824,0.0001372497,0.01330769,0.00001932885],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998776,0.000430285,0.0003109989,0.00003645833,0.0000200428,0.00005510296,0.00002448483,0.00001061419,0.0003359666],"genre_scores_gemma":[0.9982737,0.0004212772,0.0006356166,0.00004106247,0.00001717257,0.00005022349,0.00007476175,0.000002293174,0.0004839786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005989822,"threshold_uncertainty_score":0.002003849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009717852500198958,"score_gpt":0.2135990563724195,"score_spread":0.2038812038722206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}