{"id":"W1944550035","doi":"10.1186/s13041-015-0162-6","title":"Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells","year":2015,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Canadian Institutes of Health Research","keywords":"Cytosol; Psychopharmacology; Chemistry; Cell biology; Neuroscience; NF-κB; Biology; Biochemistry; Apoptosis; Pharmacology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002661663,0.0004253356,0.0002788109,0.0001541999,0.0002057034,0.0003218054,0.0003038763,0.0002909365,0.000960763],"category_scores_gemma":[0.0001116369,0.00013321,0.0002700988,0.0002238552,0.0002469184,0.0001841814,0.0002566433,0.0004636183,0.0003780826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005484,"about_ca_system_score_gemma":0.0002121923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007288831,"about_ca_topic_score_gemma":0.0009687431,"domain_scores_codex":[0.9997423,0.00003034461,0.00004878063,0.00006222916,0.00007288416,0.0000434396],"domain_scores_gemma":[0.9998598,0.00002154645,0.00003440917,0.00002517422,0.00002108383,0.00003785828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007866737,0.00004160597,0.0001241265,0.00003906462,0.000005120627,0.00006872611,0.00001774264,0.00003877167,0.9992299,0.00004326089,0.00003327484,0.0002798208],"study_design_scores_gemma":[0.0000225525,0.0002762211,0.001635073,0.000005428252,0.00001638001,0.0003439304,0.0000363459,0.00089965,0.995325,0.00003858842,0.001397469,0.000003360753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955066,0.0008379976,0.002021217,0.00007401122,0.00006086964,0.00003458824,0.0004275444,0.00007940958,0.000957645],"genre_scores_gemma":[0.9953912,0.0004183043,0.001635658,0.00003639064,0.000009796622,0.00005886663,0.0005744399,0.00001663897,0.00185868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000960763,"threshold_uncertainty_score":0.003978968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704508126173463,"score_gpt":0.2992719176710449,"score_spread":0.2722268364093103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}