{"id":"W1945161072","doi":"10.1038/npg.els.0000835","title":"Conditional Lethal Mutations as Experimental Tools","year":2001,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Organism; Biology; Genetics; Mutation; Gene; Model organism; Sequence (biology); Variety (cybernetics); Computational biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002567917,0.001308247,0.0007796602,0.003024723,0.000977066,0.002023535,0.002592692,0.001134439,0.02038182],"category_scores_gemma":[0.001694626,0.0007403889,0.000694854,0.001652473,0.001315635,0.001735609,0.002594029,0.003780153,0.01606516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008568423,"about_ca_system_score_gemma":0.0007044775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004453993,"about_ca_topic_score_gemma":0.0007776879,"domain_scores_codex":[0.9984137,0.0004683379,0.0001676764,0.0001965218,0.0006107106,0.0001430148],"domain_scores_gemma":[0.9983663,0.0007208192,0.0001454788,0.0004076687,0.0001563164,0.0002034812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004530566,0.0002570961,0.000457019,0.001444087,0.00004858041,0.001222844,0.0002137962,0.0009294733,0.6879023,0.1409873,0.05541401,0.1106704],"study_design_scores_gemma":[0.0001510602,0.0001940376,0.0007601925,0.0002995002,0.00007483429,0.001823035,0.00006399531,0.001274401,0.3196516,0.01505307,0.6605685,0.00008574338],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.0470946,0.0328999,0.6952699,0.005168777,0.005010544,0.002106572,0.02730707,0.01773379,0.1674088],"genre_scores_gemma":[0.2267993,0.04664325,0.5195227,0.00380825,0.0007443024,0.005326378,0.04086703,0.006755988,0.1495329],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02038182,"threshold_uncertainty_score":0.06818396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636251516899072,"score_gpt":0.3280484597462913,"score_spread":0.3016859445773005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}