{"id":"W1945751328","doi":"10.1111/bph.13250","title":"Cannabidiol is a negative allosteric modulator of the cannabinoid CB <sub>1</sub> receptor","year":2015,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":1006,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; King Abdulaziz University; Nova Scotia Health Research Foundation; Huntington Society of Canada","keywords":"Cannabidiol; Allosteric regulation; Allosteric modulator; Receptor; Cannabinoid receptor; Pharmacology; Cannabinoid; Chemistry; Cannabinoid receptor type 2; Functional selectivity; Agonist; Biochemistry; Biology; Medicine; Cannabis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225457,0.0003103512,0.0002698602,0.0001776917,0.0002791774,0.0002873777,0.0003358867,0.000246833,0.002479192],"category_scores_gemma":[0.0001138234,0.0001183674,0.0002650667,0.0001599365,0.0002624467,0.0001215119,0.0001602379,0.0006917218,0.0007769239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007146921,"about_ca_system_score_gemma":0.0003431701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340961,"about_ca_topic_score_gemma":0.002454727,"domain_scores_codex":[0.9998538,0.0000142343,0.00001064817,0.00002873598,0.00005446281,0.00003813487],"domain_scores_gemma":[0.9999487,0.000009925601,0.00001545607,0.000006851516,0.00000999845,0.000008984684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001967999,0.00005727291,0.0002803848,0.0001129039,0.000009416927,0.00007430916,0.00001179578,0.00007380721,0.9943098,0.0004034871,0.0001947493,0.0042754],"study_design_scores_gemma":[0.00002670146,0.0001829793,0.002755127,0.00001117977,0.00003058163,0.0003900625,0.0000163447,0.0005124153,0.9891511,0.0000792693,0.006837419,0.000006880863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564833,0.01202641,0.01054212,0.0006390407,0.0002632335,0.0002081415,0.0009530013,0.0003142265,0.01857049],"genre_scores_gemma":[0.9791666,0.005380682,0.00723993,0.0003069585,0.0000563643,0.0000888117,0.0006454088,0.00003584804,0.007079511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002479192,"threshold_uncertainty_score":0.008293748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02160515908986809,"score_gpt":0.3025486858534697,"score_spread":0.2809435267636016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}