{"id":"W1946065463","doi":"10.1210/en.2015-1162","title":"Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency","year":2015,"lang":"en","type":"article","venue":"Endocrinology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; York University","funders":"","keywords":"Autophagy; Adiponectin; Internal medicine; Endocrinology; Pressure overload; Heart failure; Cardiac function curve; Biology; Cardiac fibrosis; Medicine; Insulin resistance; Diabetes mellitus; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003265345,0.0006644296,0.0005470098,0.001080981,0.000253388,0.0003758924,0.0002691112,0.0004661792,0.002375478],"category_scores_gemma":[0.0001544781,0.0005461356,0.000403662,0.0003744783,0.0004786546,0.0004154217,0.0003361129,0.0009290959,0.000445068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135505,"about_ca_system_score_gemma":0.000164126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003067407,"about_ca_topic_score_gemma":0.0005951035,"domain_scores_codex":[0.9997717,0.00003028139,0.00004158683,0.00007036068,0.00004767121,0.00003845085],"domain_scores_gemma":[0.9996418,0.00002552614,0.0001709133,0.00002671736,0.00002003603,0.0001150754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006229068,0.0001619713,0.001042884,0.00005122436,0.00001967729,0.0004018923,0.00005455088,0.00005470008,0.9958611,0.0001117157,0.00006348419,0.001553913],"study_design_scores_gemma":[0.0003416972,0.004410286,0.1786002,0.0001197583,0.0002286548,0.006643109,0.0003921656,0.002335457,0.8021,0.0006063336,0.004161089,0.00006122981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941183,0.001102829,0.003010338,0.0001463775,0.00005679611,0.00003282114,0.0007559102,0.0001167186,0.0006599064],"genre_scores_gemma":[0.9889238,0.001464267,0.003562321,0.0002359916,0.0000513918,0.0001380645,0.0008397573,0.00009380199,0.004690583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375478,"threshold_uncertainty_score":0.007946789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525546267527145,"score_gpt":0.2720649219913974,"score_spread":0.246809459316126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}