{"id":"W1946425924","doi":"10.1111/j.1742-4658.2011.08304.x","title":"The prion protein binds thiamine","year":2011,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Alcoholism and Thiamine Deficiency","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research","keywords":"Thiamine; Biochemistry; Chemistry; Hamster; Pharmacophore; Heteronuclear molecule; Ligand (biochemistry); Docking (animal); Biology; Nuclear magnetic resonance spectroscopy; Stereochemistry; Molecular biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005772341,0.00009763063,0.0001281371,0.00006277516,0.0003566418,0.00003871699,0.0001452959,0.00005502304,0.0002261155],"category_scores_gemma":[0.000159165,0.00004952993,0.00008847131,0.0001360422,0.00008174674,0.00009256035,0.00003287618,0.0004207914,0.000159368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002910609,"about_ca_system_score_gemma":0.00009486853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008237976,"about_ca_topic_score_gemma":0.000001809728,"domain_scores_codex":[0.9990756,0.00004180702,0.0002323982,0.00009573092,0.0002940462,0.000260412],"domain_scores_gemma":[0.9994045,0.00001888577,0.0001170943,0.0002113173,0.0001083255,0.0001398943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006843075,0.002636313,0.1167236,0.0003149803,0.0008470528,0.004752799,0.01941939,0.000002009562,0.1121386,0.08022439,0.08026768,0.57583],"study_design_scores_gemma":[0.009959452,0.006325467,0.5784487,0.0006721486,0.0004527115,0.02041456,0.001990234,0.0002170207,0.06369433,0.01557886,0.3014745,0.000772022],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9374644,0.001417899,0.0002997027,0.00127155,0.0004666914,0.0002485662,9.562001e-7,0.00003416561,0.05879604],"genre_scores_gemma":[0.9919751,0.0001572608,0.0005553392,0.0001430057,0.0005041408,0.000006798609,0.000001328687,0.00001479599,0.00664218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.575058,"threshold_uncertainty_score":0.2743037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04344361580348972,"score_gpt":0.2625770706536776,"score_spread":0.2191334548501879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}