{"id":"W1946521533","doi":"10.1111/j.1600-065x.2010.00945.x","title":"B‐cell targeted therapies in human autoimmune diseases: an updated perspective","year":2010,"lang":"en","type":"review","venue":"Immunological Reviews","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Immunology; Biology; B-cell activating factor; B cell; Context (archaeology); Autoimmunity; Acquired immune system; Immune system; Autoimmune disease; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001059444,0.001846324,0.007121537,0.000703559,0.0005801374,0.0001030325,0.002732984,0.003831816,0.008511446],"category_scores_gemma":[0.0003316818,0.001226942,0.001806106,0.00103627,0.001561363,0.0002908484,0.0006896631,0.005700874,0.005795802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004170913,"about_ca_system_score_gemma":0.0003434358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003171169,"about_ca_topic_score_gemma":0.00004688557,"domain_scores_codex":[0.9885191,0.004940338,0.002874906,0.001965448,0.0001001573,0.001600036],"domain_scores_gemma":[0.9953797,0.0003395771,0.001594898,0.002414086,0.0001816365,0.00009005658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006757341,0.002090832,0.000005364573,0.0009255763,0.0004246529,0.00007324658,0.0003225302,5.45139e-8,0.1270197,0.002094306,0.0009471543,0.866029],"study_design_scores_gemma":[0.001336333,0.0007633757,0.00004544272,0.002016166,0.0007995157,0.0001351556,0.0002431405,1.082622e-7,0.0002917528,0.000626294,0.9923397,0.001402995],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000433787,0.9919971,0.000005654093,0.00005513585,0.001569663,0.003364764,0.0001798291,0.0004341419,0.001959963],"genre_scores_gemma":[0.0005007679,0.9873003,0.00009099875,0.0001262772,0.00009353445,0.0009664439,0.004743474,0.0001502957,0.006027851],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9913926,"threshold_uncertainty_score":0.9994282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04009859706010281,"score_gpt":0.3271288287554941,"score_spread":0.2870302316953913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}