{"id":"W1946641020","doi":"10.1097/shk.0000000000000392","title":"Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation","year":2015,"lang":"en","type":"article","venue":"Shock","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Ceramide; LYN; Oxidative stress; Proto-oncogene tyrosine-protein kinase Src; TLR4; Lipid raft; Lipid signaling; Kinase; Chemistry; Acid sphingomyelinase; Receptor; Biology; Signal transduction; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969538,0.0001533877,0.0001577922,0.00003628633,0.00004666335,0.00002888072,0.0001365771,0.0001201348,0.00004320607],"category_scores_gemma":[0.000102121,0.0001405078,0.00004069335,0.00008429237,0.00003021725,0.00001149343,0.0001125616,0.00008012851,0.00001564973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002133116,"about_ca_system_score_gemma":0.00006198767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002478673,"about_ca_topic_score_gemma":0.0001382213,"domain_scores_codex":[0.998984,0.0001293543,0.0001991792,0.0003254968,0.0001521542,0.0002097526],"domain_scores_gemma":[0.9994692,0.00001040449,0.00006870922,0.000248259,0.00008628258,0.0001171476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009693225,0.00006385436,0.003337262,0.000007953486,0.000009719069,0.000003964255,0.0001189091,0.00164313,0.990727,0.000004025923,0.003351225,0.0006360263],"study_design_scores_gemma":[0.0007923922,0.00007700562,0.0006056901,0.00002096368,0.000007063044,0.000003544803,0.0001758347,0.0006410427,0.990903,0.00001968021,0.006576692,0.0001770489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943753,0.00221481,0.002654589,0.00003446611,0.0003368471,0.0001480927,0.00003636062,0.00001552438,0.0001840508],"genre_scores_gemma":[0.9942479,0.0001824756,0.00367784,0.0001325601,0.0006643386,0.000008562453,0.000458283,0.00002186466,0.000606178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003225466,"threshold_uncertainty_score":0.5729743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827073562057838,"score_gpt":0.2586677848058339,"score_spread":0.2403970491852555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}