{"id":"W1946641020","doi":"10.1097/shk.0000000000000392","title":"Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation","year":2015,"lang":"en","type":"article","venue":"Shock","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Ceramide; LYN; Oxidative stress; Proto-oncogene tyrosine-protein kinase Src; TLR4; Lipid raft; Lipid signaling; Kinase; Chemistry; Acid sphingomyelinase; Receptor; Biology; Signal transduction; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598143,0.0004374451,0.0002607852,0.0004165412,0.0001701696,0.0002412027,0.000151013,0.0003432625,0.001036105],"category_scores_gemma":[0.0001118687,0.0002189699,0.0003255537,0.0001578933,0.0002183353,0.0002567921,0.0002079424,0.0006655989,0.000441319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242738,"about_ca_system_score_gemma":0.0001672461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002022819,"about_ca_topic_score_gemma":0.0002898409,"domain_scores_codex":[0.9998236,0.00003212973,0.0000189728,0.00002592844,0.00004173668,0.00005762227],"domain_scores_gemma":[0.9998924,0.00001630817,0.00002902701,0.00001290274,0.00001531275,0.00003412063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775874,0.00002906321,0.0001007028,0.0000160859,0.00000215228,0.00003149076,0.00000934626,0.00001750815,0.9991304,0.00002793809,0.000009505682,0.0004482399],"study_design_scores_gemma":[0.00005767404,0.0008151432,0.003834432,0.000005764272,0.0000160216,0.0001418524,0.0000227553,0.0004163329,0.993966,0.00005849357,0.0006614825,0.000004060734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956951,0.001175406,0.001838928,0.000102422,0.00002460326,0.00004233281,0.0002065204,0.00004862701,0.0008660149],"genre_scores_gemma":[0.9928443,0.001436899,0.00337989,0.0001048883,0.00002721324,0.00009244093,0.0004076235,0.00001936725,0.001687394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036105,"threshold_uncertainty_score":0.003466129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827073562057838,"score_gpt":0.2586677848058339,"score_spread":0.2403970491852555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}