{"id":"W1946820278","doi":"10.1111/bjh.13790","title":"Myeloma impairs mature osteoblast function but causes early expansion of osteo‐progenitors: temporal changes in bone physiology and gene expression in the KMS12BM model","year":2015,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University College London; Leukaemia and Lymphoma Research; Leukemia and Lymphoma Research; Cancer Research UK; National Institute for Health and Care Research; Organisation Canadienne des Physiciens Médicaux","keywords":"Osteoblast; Progenitor cell; Osteoclast; Bone resorption; Bone remodeling; Resorption; Cell biology; Stromal cell; Medicine; Biology; Pathology; Cancer research; Internal medicine; Stem cell; In vitro; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002532322,0.0003420398,0.0006911772,0.0005491946,0.0002370655,0.0003521552,0.0002777912,0.0005449844,0.001486666],"category_scores_gemma":[0.0001266393,0.0002545883,0.0003390662,0.0004571019,0.0003231619,0.0002266627,0.0002524802,0.001051046,0.0004456405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003189867,"about_ca_system_score_gemma":0.0002639468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001434119,"about_ca_topic_score_gemma":0.002054095,"domain_scores_codex":[0.9996458,0.00004668029,0.00003510968,0.0000514544,0.0001222984,0.00009866633],"domain_scores_gemma":[0.9998108,0.00002358517,0.00004906185,0.00002745373,0.00001721183,0.00007195324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005463085,0.0001289556,0.0003227311,0.00002838917,0.000003906726,0.0000838401,0.0000242837,0.00005533054,0.997681,0.00005526825,0.00004274059,0.001027201],"study_design_scores_gemma":[0.00006147032,0.002336,0.01519753,0.00001099203,0.00002926245,0.0006408849,0.00009129915,0.000957796,0.9782097,0.0001204024,0.002333496,0.00001113208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940104,0.001852254,0.001873443,0.0001230704,0.00002627843,0.00004978265,0.0008715129,0.000144995,0.001048183],"genre_scores_gemma":[0.991234,0.001077595,0.00233221,0.00005904889,0.00001237763,0.0001140877,0.0007311026,0.00003973371,0.004399822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486666,"threshold_uncertainty_score":0.004973352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03064421872906813,"score_gpt":0.283161634324778,"score_spread":0.2525174155957098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}