{"id":"W1948972061","doi":"10.1523/jneurosci.20-22-08384.2000","title":"Selective and Protracted Apoptosis in Human Primary Neurons Microinjected with Active Caspase-3, -6, -7, and -8","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Caspase; Apoptosis; Cell biology; Programmed cell death; Caspase 2; Caspase 3; Biology; Caspase 8; Caspase-9; Intrinsic apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007377106,0.00007637421,0.00009679575,0.00006468064,0.00007770041,0.00002532755,0.00005976361,0.00004012813,0.000001907729],"category_scores_gemma":[0.00001694048,0.00005781849,0.00001525941,0.0001463415,0.00009771276,0.00001709462,0.00001817691,0.0001144789,4.876766e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009058979,"about_ca_system_score_gemma":0.00004995605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007782152,"about_ca_topic_score_gemma":0.00001136392,"domain_scores_codex":[0.9994437,0.00004204863,0.0001314292,0.0001731761,0.00009768109,0.0001120125],"domain_scores_gemma":[0.9997239,0.00000632801,0.00009826927,0.00006086104,0.00005231675,0.00005835544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001336337,0.00004973142,0.0006817598,0.000004996543,0.000001977311,0.000009566351,0.00005192283,0.0000493174,0.9940215,0.000003760355,0.00001034689,0.004981444],"study_design_scores_gemma":[0.0006940086,0.001550274,0.5768479,0.00002491576,0.00001085233,0.0005945603,0.00002119135,0.00007546174,0.4195094,0.00002345466,0.0005477698,0.0001003034],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995297,0.00005483343,0.00006159959,0.00008072764,0.00002210272,0.0001245197,0.00000194138,0.000001768641,0.0001228059],"genre_scores_gemma":[0.9991927,0.0002145505,0.0002394014,0.0001394395,0.00002727928,0.0000018138,0.000001208511,0.000006528679,0.0001770875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5761661,"threshold_uncertainty_score":0.2357769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007017379499297299,"score_gpt":0.2268227730155557,"score_spread":0.2198053935162584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}