{"id":"W1949237644","doi":"10.1371/journal.pgen.1005573","title":"Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute on Drug Abuse; Internationale Stichting Alzheimer Onderzoek; Centre for Medical Systems Biology; National Research Foundation Singapore; Hersenstichting; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Russian Foundation for Basic Research; National Institute of Diabetes and Digestive and Kidney Diseases; ZonMw; National Cancer Institute; National Research Foundation; European Commission","keywords":"Biology; Genome-wide association study; Body mass index; Offspring; Genetics; Framingham Heart Study; Obesity; Heritability; Pedigree chart; Minor allele frequency; Waist; Internal medicine; Endocrinology; Single-nucleotide polymorphism; Framingham Risk Score; Genotype; Gene; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768324,0.0001178954,0.0002054512,0.00003228345,0.00002152141,0.000002237132,0.0002429694,0.0001619051,0.00000169261],"category_scores_gemma":[0.0003873138,0.00009299965,0.00007658511,0.0001109497,0.00007123737,7.464459e-7,0.0001159822,0.00007961409,0.000003179106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002225313,"about_ca_system_score_gemma":0.00008668974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004271482,"about_ca_topic_score_gemma":0.000168101,"domain_scores_codex":[0.9989748,0.0001769672,0.0002908842,0.0002109863,0.0001497858,0.000196547],"domain_scores_gemma":[0.9991901,0.00004036787,0.0001777293,0.0004124276,0.0001177605,0.0000616188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005428293,0.0001961672,0.8390193,0.00003796617,0.00005419066,5.052851e-7,0.0001612661,0.001047234,0.1586421,0.00001524337,0.0003742205,0.0003975466],"study_design_scores_gemma":[0.0009842293,0.0005606137,0.4673519,0.00005173882,0.00004585738,0.000002041148,0.00004315945,0.0008761054,0.5295483,0.0001519555,0.0002496112,0.0001344372],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978614,0.001000348,0.00007889486,0.00005954423,0.0002667657,0.0002573452,0.00001629173,0.000002833554,0.0004565863],"genre_scores_gemma":[0.9988303,0.0001611758,0.0007396796,0.00007298208,0.00008348523,0.00001772542,0.0000232587,0.00001279917,0.00005865074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3716674,"threshold_uncertainty_score":0.3792416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068337992710607,"score_gpt":0.2581751737613202,"score_spread":0.2374917938342141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}