{"id":"W1949323217","doi":"10.1111/cbdd.12082","title":"Dynamic Change of Heme Environment in Soluble Guanylate Cyclase and Complexation of NO‐Independent Drug Agents with H‐NOX Domain","year":2012,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Heme; Chemistry; Cyclic guanosine monophosphate; Docking (animal); Allosteric regulation; Nitric oxide; GUCY1B3; Biochemistry; Binding site; Ligand (biochemistry); Biophysics; Cyclase; Enzyme; Guanylate cyclase 2C; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502734,0.0001519819,0.0002220949,0.0000400958,0.00001932184,0.000002004182,0.0000914314,0.0001651752,0.00004916832],"category_scores_gemma":[0.00001495777,0.0001245552,0.00003627608,0.00004615402,0.0001977812,0.000007650898,0.00008067204,0.00008668677,0.000005619586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002788282,"about_ca_system_score_gemma":0.00001444427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002656812,"about_ca_topic_score_gemma":0.000004870789,"domain_scores_codex":[0.9990808,0.00009242818,0.0002431307,0.0002575897,0.0000749596,0.0002510858],"domain_scores_gemma":[0.9995433,0.00002279643,0.0001403877,0.0001953121,0.00002320898,0.00007497973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002486267,0.00009818279,0.01804602,0.00002866019,0.00003625605,6.358302e-7,0.000195246,0.000006229438,0.9802266,0.00002332867,0.0002070666,0.0008831999],"study_design_scores_gemma":[0.001403295,0.0002016596,0.01213902,0.00002387213,0.00003246132,0.00001279139,0.00008433492,0.0002211997,0.9829341,0.000255738,0.002463965,0.0002275724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961793,0.0006603511,0.002560836,0.00006295887,0.000078652,0.0002909937,0.00001622615,0.000004317174,0.0001463998],"genre_scores_gemma":[0.9960002,0.000164222,0.003397409,0.00008323848,0.00005572091,0.00003174495,0.0001806609,0.00001231742,0.00007450354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005906994,"threshold_uncertainty_score":0.5079216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498115918718398,"score_gpt":0.2321607697692538,"score_spread":0.2171796105820698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}