{"id":"W1949323217","doi":"10.1111/cbdd.12082","title":"Dynamic Change of Heme Environment in Soluble Guanylate Cyclase and Complexation of NO‐Independent Drug Agents with H‐NOX Domain","year":2012,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Heme; Chemistry; Cyclic guanosine monophosphate; Docking (animal); Allosteric regulation; Nitric oxide; GUCY1B3; Biochemistry; Binding site; Ligand (biochemistry); Biophysics; Cyclase; Enzyme; Guanylate cyclase 2C; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145772,0.0001605835,0.0002512654,0.00007099313,0.0001755995,0.0001940467,0.0001965417,0.0001773018,0.0006678127],"category_scores_gemma":[0.0002007271,0.00008743302,0.000201763,0.0001175985,0.0001499762,0.0002239235,0.000148375,0.0002060777,0.00006247764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003026575,"about_ca_system_score_gemma":0.0001488371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001479173,"about_ca_topic_score_gemma":0.001023073,"domain_scores_codex":[0.9999151,0.00001317851,0.000003115372,0.00002291452,0.00003006117,0.00001569071],"domain_scores_gemma":[0.9999667,0.00001020424,0.000008976777,0.000002337069,0.000004915759,0.000006939508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004728406,0.0001289429,0.005846248,0.0001728091,0.00006919516,0.0003311735,0.00008768018,0.02564328,0.9609328,0.0009839259,0.0003326987,0.004998442],"study_design_scores_gemma":[0.00007972376,0.0008145196,0.01407569,0.00001293592,0.00006968228,0.0003014033,0.0001352574,0.2615656,0.7195262,0.0005639906,0.002809743,0.00004544936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982968,0.0003222015,0.000880504,0.00003768817,0.000005273922,0.0000045451,0.00004949879,0.00001364028,0.0003898899],"genre_scores_gemma":[0.9987004,0.0001760699,0.0007692187,0.00001855473,0.000001356879,0.00000496438,0.00009561981,0.000003388119,0.0002304355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479173,"threshold_uncertainty_score":0.002941072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498115918718398,"score_gpt":0.2321607697692538,"score_spread":0.2171796105820698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}