{"id":"W1949617006","doi":"10.1093/jnci/djv170","title":"Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome","year":2015,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Medicine; Lynch syndrome; MLH1; Aspirin; Colorectal cancer; Internal medicine; Hazard ratio; MSH6; PMS2; Germline mutation; Population; Oncology; Cancer; Confidence interval; Mutation; Genetics; DNA mismatch repair; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005652843,0.0002635783,0.0002254838,0.0006487274,0.0002453414,0.0004124343,0.0002223839,0.000500272,0.001298635],"category_scores_gemma":[0.002649442,0.0002013809,0.000481615,0.0009238643,0.0001580515,0.000201698,0.0002709461,0.0004223426,0.0001337632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244846,"about_ca_system_score_gemma":0.0002721017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004455652,"about_ca_topic_score_gemma":0.004250187,"domain_scores_codex":[0.9996933,0.0001118888,0.00003923354,0.00004773826,0.00006988853,0.00003806164],"domain_scores_gemma":[0.9984231,0.0003228914,0.0009279733,0.00007107175,0.00007231465,0.0001825865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005919072,0.00004106472,0.9964175,0.00003787579,0.0001927458,0.0001428267,0.0000259576,0.00005607184,0.0002373997,0.00002094093,0.00009229356,0.002143436],"study_design_scores_gemma":[0.00002369276,0.0001837903,0.9986181,0.00001315422,0.0001596811,0.0004373555,0.00002824271,0.0001939861,0.00005182071,0.00004173715,0.0002452851,0.000003109913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948127,0.0042026,0.000070554,0.0001437676,0.00001407172,0.000008116903,0.00028689,0.000006120787,0.0004551301],"genre_scores_gemma":[0.9986982,0.0008142329,0.00008214133,0.00002367541,0.00002034429,0.000004384463,0.0001925404,0.000001375842,0.000163158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004455652,"threshold_uncertainty_score":0.008859456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04664612316987149,"score_gpt":0.3369513127154388,"score_spread":0.2903051895455673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}