{"id":"W1949822692","doi":"10.1111/acel.12368","title":"Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging","year":2015,"lang":"en","type":"article","venue":"Aging Cell","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":467,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Canada Research Chairs; University of New Brunswick; University of Toronto; Pacific Centre for Reproductive Medicine; CReATe Fertility Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Oocyte; Biology; Infertility; Mitochondrion; Andrology; Coenzyme Q10; Endocrinology; Ovarian reserve; Internal medicine; SIRT3; Pregnancy; Cell biology; Embryo; Genetics; Sirtuin; Medicine; Acetylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042925,0.0002217919,0.0002813401,0.0002572673,0.0001202503,0.0001696539,0.0002861414,0.0002687405,0.0008882975],"category_scores_gemma":[0.0002055996,0.0001199575,0.0001757265,0.0001238612,0.0002833504,0.000214991,0.0002172497,0.0003701044,0.0001287541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002324321,"about_ca_system_score_gemma":0.0002837316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001707621,"about_ca_topic_score_gemma":0.002063206,"domain_scores_codex":[0.9999254,0.00001389787,0.000008933518,0.0000138139,0.00001688206,0.00002103105],"domain_scores_gemma":[0.9998368,0.00001728534,0.00004637175,0.00002003225,0.00002397567,0.00005549776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005907764,0.00007494433,0.0005705949,0.00004503279,0.00001047765,0.0001071527,0.00003706006,0.00004323593,0.9947658,0.0001409318,0.00006515619,0.003548841],"study_design_scores_gemma":[0.0001216863,0.003035124,0.02299591,0.00001449962,0.00004685696,0.0005953489,0.0001233401,0.0005080994,0.9656992,0.0001978917,0.006650981,0.00001101824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956115,0.001797403,0.001460741,0.0001539044,0.00005519607,0.00002749148,0.0001998277,0.00005336314,0.0006406357],"genre_scores_gemma":[0.9951834,0.001166839,0.0008006201,0.000059549,0.00001302183,0.00002518925,0.0002266996,0.00001774269,0.002507046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707621,"threshold_uncertainty_score":0.003395319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132680489546206,"score_gpt":0.2325818704283935,"score_spread":0.2212550655329314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}