{"id":"W1950838216","doi":"10.3390/v7092856","title":"Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Virology; Antibody-dependent cell-mediated cytotoxicity; Neutralization; Antibody; Biology; Effector; Epitope; Neutralizing antibody; Immunization; Virus; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006922681,0.0005617227,0.001842311,0.0003280834,0.0002291548,0.0000636267,0.0003316117,0.0005020809,0.0001616586],"category_scores_gemma":[0.0001344422,0.0004200847,0.0002627363,0.0001246709,0.000405165,0.0002399393,0.0002690209,0.0004792796,0.0008845478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298385,"about_ca_system_score_gemma":0.0004044056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001712075,"about_ca_topic_score_gemma":0.00002068553,"domain_scores_codex":[0.9973038,0.0005751768,0.0008809213,0.0004740091,0.0001778634,0.0005882268],"domain_scores_gemma":[0.9980832,0.0006220512,0.0007224412,0.0003128859,0.000155299,0.0001041698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002822414,0.0004199527,0.0009085145,0.008801293,0.004648706,0.00005443185,0.0009890284,0.00000231267,0.005490064,0.00008134235,0.0335964,0.9447257],"study_design_scores_gemma":[0.001848472,0.0001537569,0.00002440045,0.005245198,0.0003965504,0.00004869533,0.0002151748,6.15119e-7,0.009615635,0.00001089,0.9820037,0.0004369175],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003303865,0.9901039,0.00002180798,0.00004927147,0.000473532,0.0009005308,0.004420429,0.0000607316,0.0006659137],"genre_scores_gemma":[0.003474085,0.9905446,0.0001343948,0.00006898811,0.00004485533,0.0001128252,0.005091849,0.00004822999,0.0004802082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9484073,"threshold_uncertainty_score":0.9998934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08729650803625864,"score_gpt":0.332190693214722,"score_spread":0.2448941851784633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}