{"id":"W1950838216","doi":"10.3390/v7092856","title":"Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Virology; Antibody-dependent cell-mediated cytotoxicity; Neutralization; Antibody; Biology; Effector; Epitope; Neutralizing antibody; Immunization; Virus; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004005763,0.000674242,0.0008282283,0.001327975,0.0002028012,0.0007507413,0.0006393029,0.0008408236,0.002148403],"category_scores_gemma":[0.0003486328,0.0003033746,0.0003177444,0.0009933823,0.0004327171,0.001030243,0.0005363089,0.001264596,0.001693865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005458557,"about_ca_system_score_gemma":0.0005072528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005597381,"about_ca_topic_score_gemma":0.0009486678,"domain_scores_codex":[0.9998957,0.00001696566,0.00001085109,0.00002026218,0.00003895125,0.00001724191],"domain_scores_gemma":[0.9999069,0.0000326091,0.00001591935,0.00000498652,0.00002740881,0.00001211244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008266082,0.00007376389,0.0001829515,0.008834472,0.00005935909,0.0002158568,0.00006059973,0.000509472,0.01023017,0.006786482,0.02189388,0.9510702],"study_design_scores_gemma":[0.00001372541,0.00009003555,0.0006379666,0.000768251,0.00003923438,0.0008172637,0.00002799957,0.0001152109,0.00299024,0.001292044,0.9931939,0.00001420627],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004401888,0.9967728,0.000325861,0.0002312155,0.0002108245,0.000008458938,0.00001973738,0.00001177717,0.001979054],"genre_scores_gemma":[0.002407909,0.9952495,0.0003091844,0.0001822333,0.0001191498,0.00001255982,0.00003566279,0.000002688416,0.00168105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002148403,"threshold_uncertainty_score":0.007187068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08729650803625864,"score_gpt":0.332190693214722,"score_spread":0.2448941851784633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}