{"id":"W1950875559","doi":"10.1073/pnas.1507793112","title":"Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Research Council; National Institutes of Health; International AIDS Vaccine Initiative; Universiteit van Amsterdam; California HIV/AIDS Research Program; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Epitope; Clade; Virology; Biology; Human immunodeficiency virus (HIV); HIV vaccine; AIDS Vaccines; Glycoprotein; Antigen; Antibody; Immunization; Gp41; Recombinant DNA; Neutralizing antibody; Virus; Phylogenetic tree; Immunology; Genetics; Gene; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012798,0.00009774614,0.0001985048,0.0001372503,0.0001793142,0.000007161431,0.0005735033,0.0000893068,0.00002621762],"category_scores_gemma":[0.0003782903,0.00004991042,0.00005721512,0.0003280251,0.002600378,0.0001757929,0.0001538406,0.000201573,0.000001970549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000264125,"about_ca_system_score_gemma":0.0001354944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005526582,"about_ca_topic_score_gemma":2.351434e-7,"domain_scores_codex":[0.9990045,0.00005608252,0.0002459604,0.0001675437,0.00035867,0.000167196],"domain_scores_gemma":[0.998933,0.0003428563,0.0003913394,0.00001384136,0.0002934869,0.00002548407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002222252,0.00006406302,0.007289092,0.00002204343,0.0001530913,1.295497e-8,0.001018663,0.00004583788,0.9836995,0.005697913,0.001439451,0.0003481249],"study_design_scores_gemma":[0.001120109,0.0001885447,0.02041604,0.00004321977,0.00003870305,0.00002799677,0.001029983,0.00004522617,0.9637816,0.01298896,0.0002613488,0.00005825214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957798,0.00180059,0.000004025889,0.001125552,0.0000197877,0.0002799982,0.000132756,0.00000367283,0.0008537956],"genre_scores_gemma":[0.9990262,0.00006708453,0.0006682752,0.00004666682,0.000009937576,0.000004963862,0.000001465163,0.000002672765,0.0001726674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01991786,"threshold_uncertainty_score":0.9581201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06570366641642628,"score_gpt":0.3179054442182745,"score_spread":0.2522017778018482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}