{"id":"W1950875559","doi":"10.1073/pnas.1507793112","title":"Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Research Council; National Institutes of Health; International AIDS Vaccine Initiative; Universiteit van Amsterdam; California HIV/AIDS Research Program; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Epitope; Clade; Virology; Biology; Human immunodeficiency virus (HIV); HIV vaccine; AIDS Vaccines; Glycoprotein; Antigen; Antibody; Immunization; Gp41; Recombinant DNA; Neutralizing antibody; Virus; Phylogenetic tree; Immunology; Genetics; Gene; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176157,0.000212608,0.0001524239,0.0001342883,0.000158619,0.0002394153,0.000341399,0.0002668521,0.0008684343],"category_scores_gemma":[0.0001559777,0.0001450143,0.0002087945,0.0001436137,0.0001170834,0.0001198071,0.0001517315,0.0005004191,0.000336711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004762727,"about_ca_system_score_gemma":0.0002017973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101224,"about_ca_topic_score_gemma":0.0005937611,"domain_scores_codex":[0.9999495,0.000008878949,0.000005047304,0.000009729786,0.00001623981,0.00001070635],"domain_scores_gemma":[0.9999523,0.000002755613,0.00001413559,0.000004606373,0.000008869098,0.00001731915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003658244,0.00008545087,0.0008349653,0.00004905828,0.00001656572,0.000168215,0.00005902065,0.002743381,0.9917867,0.0004514074,0.0001328739,0.003306603],"study_design_scores_gemma":[0.0002417961,0.001369236,0.008920155,0.00001974104,0.0000749445,0.000621198,0.0001442802,0.02155601,0.9601021,0.0002236864,0.006694041,0.00003274423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996058,0.000258406,0.002438079,0.00006212921,0.000008558182,0.00006352922,0.0002312412,0.00002653778,0.0008535702],"genre_scores_gemma":[0.9853488,0.0003349766,0.01090931,0.00009296179,0.000004118305,0.00006122021,0.001089568,0.00001908086,0.002139879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101224,"threshold_uncertainty_score":0.003455579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06570366641642628,"score_gpt":0.3179054442182745,"score_spread":0.2522017778018482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}