{"id":"W1951686626","doi":"10.1593/neo.10804","title":"Development of a Resistance-like Phenotype to Sorafenib by Human Hepatocellular Carcinoma Cells Is Reversible and Can Be Delayed by Metronomic UFT Chemotherapy","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre","funders":"National Cancer Institute; National Institutes of Health; Canadian Cancer Society Research Institute; Government of Ontario; Ontario Institute for Cancer Research","keywords":"Sorafenib; Medicine; Hepatocellular carcinoma; Regimen; Chemotherapy; Oncology; Pharmacology; Internal medicine; Cancer research; Tegafur; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161692,0.0002424935,0.0003278223,0.0001315266,0.00009817445,0.0002173079,0.0001007552,0.0001647038,0.001467807],"category_scores_gemma":[0.0001451666,0.0001147327,0.0002701851,0.0001011666,0.00008962369,0.0001290931,0.0001003682,0.0003854259,0.0003733433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894909,"about_ca_system_score_gemma":0.0001523341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006716925,"about_ca_topic_score_gemma":0.0007697344,"domain_scores_codex":[0.9998837,0.00002666944,0.00001237442,0.00001745627,0.00002872166,0.00003112225],"domain_scores_gemma":[0.9998933,0.00002355982,0.00002275596,0.00002497952,0.0000123229,0.00002313293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001933877,0.00008023052,0.0003653822,0.00001219154,0.000004888821,0.0000492149,0.00001345324,0.00007138484,0.9981909,0.00003743419,0.000042163,0.0009393133],"study_design_scores_gemma":[0.00004548586,0.001878073,0.0123784,0.000003048915,0.00001256109,0.0004293396,0.00002437317,0.001217785,0.9825126,0.00001842407,0.001473967,0.000006123036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979037,0.0004568472,0.0006413028,0.00003292708,0.00001261643,0.00002805738,0.0001881264,0.00005826657,0.000678181],"genre_scores_gemma":[0.9977468,0.0002663915,0.0005224633,0.00001626005,0.000004387942,0.00003337401,0.0003958329,0.00001078464,0.00100367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467807,"threshold_uncertainty_score":0.00491029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02096543147053348,"score_gpt":0.2322336718951053,"score_spread":0.2112682404245718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}