{"id":"W1952352960","doi":"10.1002/ptr.5327","title":"A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer","year":2015,"lang":"en","type":"review","venue":"Phytotherapy Research","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canada Research Chairs; U.S. Department of Veterans Affairs","keywords":"Janus kinase; stat; STAT protein; JAK-STAT signaling pathway; Signal transduction; Curcumin; STAT3; Cancer research; Biology; Cancer cell; Cell growth; Cell signaling; Cell biology; Cancer; Pharmacology; Tyrosine kinase; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248985,0.0008551975,0.00106266,0.002694655,0.0003178835,0.0007507878,0.0006135842,0.000796075,0.005439778],"category_scores_gemma":[0.0003996266,0.0002441318,0.0004622578,0.002329387,0.0002280872,0.001035388,0.000492375,0.001273795,0.002454875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003755315,"about_ca_system_score_gemma":0.0007232543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007550652,"about_ca_topic_score_gemma":0.001616868,"domain_scores_codex":[0.9998865,0.00001482444,0.00002217567,0.00002171809,0.00004329683,0.00001147794],"domain_scores_gemma":[0.9998184,0.00006598741,0.00003399333,0.000005022588,0.00005170931,0.00002492652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001103847,0.0001222105,0.0002056446,0.0380286,0.0001409757,0.0003570686,0.00007406819,0.0003076963,0.004781965,0.001914243,0.06487165,0.8890856],"study_design_scores_gemma":[0.00001720425,0.00009613237,0.0007752294,0.003029345,0.0001370932,0.001348335,0.00003795253,0.00004990256,0.0006412673,0.000733319,0.9931175,0.0000167593],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001728262,0.9979947,0.0001188552,0.0002236575,0.0003258154,0.000007773015,0.0000411904,0.00001149078,0.001103787],"genre_scores_gemma":[0.0006422557,0.9977909,0.0001979773,0.0002169316,0.0001926104,0.000007608022,0.00006292586,0.000001874417,0.0008868414],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005439778,"threshold_uncertainty_score":0.01819789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1665245021313322,"score_gpt":0.4863870265264265,"score_spread":0.3198625243950942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}