{"id":"W1952352960","doi":"10.1002/ptr.5327","title":"A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer","year":2015,"lang":"en","type":"review","venue":"Phytotherapy Research","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canada Research Chairs; U.S. Department of Veterans Affairs","keywords":"Janus kinase; stat; STAT protein; JAK-STAT signaling pathway; Signal transduction; Curcumin; STAT3; Cancer research; Biology; Cancer cell; Cell growth; Cell signaling; Cell biology; Cancer; Pharmacology; Tyrosine kinase; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002164789,0.0005522468,0.001527883,0.0002147253,0.0001098541,0.0000624907,0.0006406254,0.0004890951,0.00007983133],"category_scores_gemma":[0.0003638361,0.000465794,0.00027209,0.0004447313,0.0002794221,0.000009666571,0.0004162865,0.0009447805,0.00001547702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533694,"about_ca_system_score_gemma":0.0005345391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004262691,"about_ca_topic_score_gemma":0.00001422353,"domain_scores_codex":[0.9958418,0.0008206149,0.0007886769,0.001191322,0.000481626,0.0008759736],"domain_scores_gemma":[0.9982428,0.0001413476,0.0002910524,0.000649752,0.0003946517,0.0002804184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001317413,0.0002113378,0.00006469397,0.03919193,0.0001800905,0.00001082216,0.0001770404,0.000002222024,0.3259087,0.000003476003,0.07498477,0.5591331],"study_design_scores_gemma":[0.0004083118,0.0001080658,7.052299e-7,0.0265439,0.00003252264,0.000005210391,0.00003771495,0.000001722504,0.03809696,0.0001188607,0.9341643,0.0004817517],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008445665,0.996897,0.00001923226,0.00006814155,0.00008489155,0.001654038,0.0001415314,0.0000120644,0.0002784971],"genre_scores_gemma":[0.00008670948,0.9963358,0.0004738828,0.0001988775,0.0009324239,0.001085209,0.0004002676,0.0001363729,0.0003504459],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8591795,"threshold_uncertainty_score":0.9997794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1665245021313322,"score_gpt":0.4863870265264265,"score_spread":0.3198625243950942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}