{"id":"W1952439670","doi":"10.1073/pnas.1512869112","title":"Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Casein kinase 2; Biology; Progenitor cell; Skeletal muscle; Stem cell; Transcription factor; Cellular differentiation; Phosphorylation; Chemistry; Protein kinase A; Biochemistry; Anatomy; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266711,0.0003844575,0.0002537305,0.0002330423,0.0001322208,0.0003283776,0.0002523315,0.0003303338,0.002276864],"category_scores_gemma":[0.0002156607,0.0001529898,0.0003294861,0.0001268028,0.0002923501,0.0002199605,0.0001877412,0.0007661807,0.0004022668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003149528,"about_ca_system_score_gemma":0.0003721742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003197354,"about_ca_topic_score_gemma":0.0004575418,"domain_scores_codex":[0.9997398,0.00005197999,0.00003273017,0.00003975999,0.00007216859,0.00006337858],"domain_scores_gemma":[0.9998554,0.00004502585,0.00003089241,0.00001854141,0.00001506486,0.00003514565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155901,0.00004380864,0.0001370404,0.00003813557,0.00001024791,0.00002814962,0.000008028842,0.00006406382,0.99821,0.0001521899,0.00003530312,0.001117163],"study_design_scores_gemma":[0.00002863442,0.0002240087,0.001061036,0.000004543912,0.000008443647,0.0001964584,0.00001036409,0.0008508732,0.9967735,0.0000695722,0.000770587,0.000001873424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911112,0.00235254,0.00388044,0.0001820802,0.00005748793,0.00003263279,0.0001681962,0.0000756958,0.002139707],"genre_scores_gemma":[0.9954967,0.0007199997,0.001650328,0.00005630175,0.000009971445,0.00002604666,0.0003278921,0.00001241287,0.001700258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002276864,"threshold_uncertainty_score":0.007616878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03338441749794406,"score_gpt":0.2883704701475944,"score_spread":0.2549860526496503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}