{"id":"W1952439670","doi":"10.1073/pnas.1512869112","title":"Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Casein kinase 2; Biology; Progenitor cell; Skeletal muscle; Stem cell; Transcription factor; Cellular differentiation; Phosphorylation; Chemistry; Protein kinase A; Biochemistry; Anatomy; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006063071,0.00006458772,0.0001181062,0.00005321603,0.00003449349,0.000002189942,0.0003824538,0.00009889464,0.0000019648],"category_scores_gemma":[0.0001983452,0.00004595244,0.00006193495,0.000224392,0.0006273536,0.00001353043,0.0001255521,0.00005226933,3.923271e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004138619,"about_ca_system_score_gemma":0.00005830363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008265514,"about_ca_topic_score_gemma":1.762311e-7,"domain_scores_codex":[0.9991307,0.000007905067,0.0002401687,0.000156134,0.0003727137,0.00009244157],"domain_scores_gemma":[0.9993235,0.00001949221,0.0003542036,0.00001048063,0.0002604564,0.00003188846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005264516,0.00006440363,0.002742166,0.0000519265,0.00001549,1.322143e-9,0.0001245763,0.00003978316,0.9933023,0.002833067,0.0006613622,0.000112237],"study_design_scores_gemma":[0.0002089197,0.0001480167,0.006012025,0.00001963643,0.000008403576,0.00000102475,0.0001800819,0.00002180342,0.9840911,0.009057096,0.0002042668,0.00004763421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918081,0.0003815944,4.244013e-7,0.0002292835,0.00001583955,0.00007649478,0.00001429725,0.000002027851,0.007471962],"genre_scores_gemma":[0.9991466,0.0001099027,0.0005689392,0.00009044491,0.00003461295,0.000001981385,5.113263e-7,0.000002377278,0.00004466771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009211252,"threshold_uncertainty_score":0.231151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03338441749794406,"score_gpt":0.2883704701475944,"score_spread":0.2549860526496503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}