{"id":"W1952799215","doi":"10.1002/9780470571224.pse188","title":"Preclinical Safety Evaluation of Immunotoxins","year":2010,"lang":"en","type":"other","venue":"Pharmaceutical Sciences Encyclopedia","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Pseudomonas exotoxin; In vivo; In vitro; Recombinant DNA; Antibody; Exotoxin; Cancer research; Computational biology; Medicine; Chemistry; Toxin; Immunology; Biology; Monoclonal antibody; Microbiology; Biotechnology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003417738,0.0003881138,0.0006084983,0.0002644486,0.0001922,0.00001996062,0.00101163,0.001054751,0.07858305],"category_scores_gemma":[0.0006437283,0.0003100524,0.0002314258,0.0003518039,0.001626935,0.00008565914,0.0002702316,0.001166154,0.001240745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004561104,"about_ca_system_score_gemma":0.000515995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001711571,"about_ca_topic_score_gemma":0.0001150449,"domain_scores_codex":[0.996905,0.0006066628,0.000730621,0.0007181481,0.000406473,0.0006331529],"domain_scores_gemma":[0.9985528,0.0003085629,0.000442413,0.0005081095,0.0001177514,0.0000703516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002116093,0.001152887,0.00066111,0.0001521843,0.0005821559,0.000003358814,0.0002755505,0.000008917399,0.2810552,0.01150848,0.1872507,0.5171378],"study_design_scores_gemma":[0.001446474,0.0001567037,0.0003746594,0.0001097344,0.0003560495,0.0000116617,0.00003051832,0.000070796,0.01405195,0.0004316868,0.9825733,0.0003865093],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00133203,0.0147022,0.0001361097,0.0001491081,0.006394819,0.001094695,0.0002169941,0.0001771335,0.9757969],"genre_scores_gemma":[0.09122441,0.01992892,0.003671667,0.0005888135,0.001138243,0.0003093005,0.000410537,0.000655817,0.8820723],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.7953226,"threshold_uncertainty_score":0.9999352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06463846988649058,"score_gpt":0.3847948038219513,"score_spread":0.3201563339354607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}