{"id":"W1953104269","doi":"10.1111/j.1440-1681.2011.05572.x","title":"Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart","year":2011,"lang":"en","type":"article","venue":"Clinical and Experimental Pharmacology and Physiology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Bradykinin; Aliskiren; Kallikrein; Internal medicine; Messenger RNA; Endocrinology; Chemistry; Cardiology; Medicine; Renin–angiotensin system; Biochemistry; Blood pressure; Enzyme; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002176135,0.0006441652,0.0007201284,0.0004439145,0.0001623143,0.0004177847,0.0002304272,0.0003927021,0.001604569],"category_scores_gemma":[0.000204418,0.0003008939,0.0004881418,0.0001647824,0.0003881242,0.000394967,0.000192483,0.0009990195,0.0003843181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002931654,"about_ca_system_score_gemma":0.0001942491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004059408,"about_ca_topic_score_gemma":0.0008855833,"domain_scores_codex":[0.9996514,0.00004525738,0.00004301735,0.0001043489,0.00008692105,0.00006907609],"domain_scores_gemma":[0.9995306,0.00004114013,0.0001942973,0.00004340526,0.00004883821,0.000141746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003025942,0.00002489394,0.0001016999,0.00003116165,0.000006765464,0.00002443373,0.000007284148,0.000009186003,0.999046,0.00001011331,0.000009075078,0.0004267344],"study_design_scores_gemma":[0.00007076664,0.002686762,0.01824548,0.000009717362,0.00008782836,0.0002662689,0.00006198266,0.0002400147,0.977356,0.00003089261,0.0009344922,0.000009884696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928713,0.003607651,0.00191823,0.00009250748,0.00007197305,0.00003606629,0.0003936349,0.0001093444,0.0008992177],"genre_scores_gemma":[0.9890808,0.003331881,0.00341379,0.0001869603,0.00007644641,0.00007491405,0.0007773225,0.00005072449,0.003007159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001604569,"threshold_uncertainty_score":0.005367756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09220454485990265,"score_gpt":0.404133457449826,"score_spread":0.3119289125899233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}