{"id":"W1953948364","doi":"10.1016/j.immuni.2015.08.013","title":"The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity","year":2015,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":342,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Genentech","keywords":"Colorectal cancer; Inflammasome; Biology; Cancer research; Natural killer cell; Immunology; Cancer; Cytotoxicity; Biochemistry; Genetics; Inflammation; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986496,0.0002857279,0.0003795843,0.0002760178,0.0001722148,0.0003992852,0.0001655336,0.0003067486,0.002175744],"category_scores_gemma":[0.000195667,0.0001256015,0.000262794,0.0001868146,0.0003783404,0.0002873988,0.000204934,0.00108427,0.0004009655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427778,"about_ca_system_score_gemma":0.0003575835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003851497,"about_ca_topic_score_gemma":0.0006631627,"domain_scores_codex":[0.9998235,0.00003887912,0.00002105885,0.00002294483,0.00004008452,0.00005359958],"domain_scores_gemma":[0.9998703,0.00001118413,0.00003867959,0.00001882562,0.00001255631,0.00004841553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003144358,0.0002969259,0.0004595868,0.0001144623,0.00002266341,0.0001081982,0.00002787601,0.0001866036,0.9878214,0.0003490504,0.0004721363,0.00699678],"study_design_scores_gemma":[0.0007965881,0.003918578,0.006243372,0.00001990554,0.00006771231,0.000731104,0.000116268,0.002323171,0.9790156,0.0005174371,0.006234403,0.00001595947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917202,0.002533138,0.002362903,0.0006668099,0.0001508568,0.00003709443,0.0003984864,0.0002687058,0.001861763],"genre_scores_gemma":[0.9968914,0.0005430623,0.0006088806,0.000104867,0.00002180337,0.00002325617,0.000159062,0.00001789108,0.001629858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175744,"threshold_uncertainty_score":0.007278621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015282025203651,"score_gpt":0.2443813523014139,"score_spread":0.2342285320493774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}