{"id":"W1954263225","doi":"10.4049/jimmunol.1002046","title":"IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":417,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Takeda Oncology; National Cancer Institute; Yale University; National Institutes of Health; American Lebanese Syrian Associated Charities; National Institute of Allergy and Infectious Diseases; Vlaamse regering; St. Jude Children's Research Hospital","keywords":"Inflammasome; Azoxymethane; Inflammation; Proinflammatory cytokine; Carcinogenesis; Colorectal cancer; Cancer research; Nod; Effector; Immunology; Cancer; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005576268,0.000110785,0.0001460617,0.00006544573,0.0001441503,0.000008605868,0.0003327055,0.0001240929,0.00001378928],"category_scores_gemma":[0.0003304691,0.00006480655,0.0001255838,0.0001124441,0.0003152391,0.0000228492,0.00007807034,0.0004151646,0.000003762386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001498275,"about_ca_system_score_gemma":0.0001263681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001003444,"about_ca_topic_score_gemma":0.00005207839,"domain_scores_codex":[0.9990619,0.0001745721,0.0004158765,0.00007442077,0.0001159222,0.0001572766],"domain_scores_gemma":[0.9986808,0.00001109542,0.0006725926,0.0002877162,0.0003340817,0.00001376804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000562197,0.00004233604,0.0001999177,0.000008579355,0.00009352092,4.098553e-7,0.0002393807,0.0001086757,0.99101,0.00002330653,0.0002298298,0.007481921],"study_design_scores_gemma":[0.0006119988,0.0005365816,0.009443234,0.00001659825,0.00003565709,0.0004464053,0.0005877202,0.00002046959,0.9781908,0.00007956334,0.00995456,0.00007643617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970943,0.0003000791,0.00005747566,0.0006471997,0.001183019,0.0002903345,0.000002537503,0.000003682695,0.0004214002],"genre_scores_gemma":[0.99928,0.0003478354,0.00002756423,0.0000508269,0.00018346,0.000007543632,0.00000630863,0.00001030813,0.00008611421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01281915,"threshold_uncertainty_score":0.2642735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005786981260014884,"score_gpt":0.2029850456915568,"score_spread":0.1971980644315419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}