{"id":"W1954522611","doi":"10.1016/j.clpt.2003.11.009","title":"Probing opioid effects in major depression hydromorphone (HM) challenge","year":2004,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Placebo; Opioid; Major depressive disorder; Depression (economics); Medicine; Internal medicine; Hamd; Psychology; Hydromorphone; Anesthesia; Mood; Psychiatry; Significant difference; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894968,0.000272775,0.0006903388,0.00008063162,0.0001137681,0.0001166502,0.0001636529,0.0003455094,0.00125409],"category_scores_gemma":[0.0003410604,0.0001524123,0.0001704219,0.0000795932,0.0001714242,0.0001092726,0.0001165892,0.0005104525,0.000137311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001345205,"about_ca_system_score_gemma":0.0001580323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004029052,"about_ca_topic_score_gemma":0.001220497,"domain_scores_codex":[0.9998853,0.00003902265,0.00001006081,0.00001706626,0.00002801541,0.00002051487],"domain_scores_gemma":[0.9998158,0.00004340762,0.00005687907,0.00001505017,0.00001372052,0.00005520026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.102237,0.006808055,0.01129746,0.0005920528,0.0002308093,0.0002754964,0.0001719566,0.0006058236,0.8295588,0.00006599831,0.0004229686,0.04773365],"study_design_scores_gemma":[0.01529315,0.5535572,0.2718711,0.00004315245,0.0002820483,0.0009116648,0.0001693681,0.002262426,0.1527368,0.0001143379,0.002716153,0.00004266687],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990093,0.0004647029,0.0001448246,0.00002409302,0.00001623377,0.00009497112,0.0001028365,0.000008480562,0.0001345595],"genre_scores_gemma":[0.9981619,0.0004312626,0.00040116,0.00006794152,0.00002483837,0.0001412382,0.0001495206,0.000001625133,0.0006205824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125409,"threshold_uncertainty_score":0.004195333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06385215346772229,"score_gpt":0.4052982068413665,"score_spread":0.3414460533736443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}