{"id":"W1955243940","doi":"10.3233/jad-2009-1037","title":"A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor","year":2009,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"PDZ domain; Proteases; Peptide; Chemistry; Intracellular; Cell biology; Serine protease; Protease; Biochemistry; Amyloid beta; Chaperone (clinical); Biology; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497551,0.0001955489,0.0003951219,0.0003427033,0.00008673049,0.00003230351,0.0001068706,0.00006447734,0.0004598068],"category_scores_gemma":[0.00005965555,0.000156567,0.0003158996,0.0002923001,0.00005408559,0.0005321343,0.000014012,0.0001864724,0.00003499117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004504544,"about_ca_system_score_gemma":0.0008941008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002488131,"about_ca_topic_score_gemma":7.695045e-7,"domain_scores_codex":[0.9980409,0.0000789055,0.0005842932,0.0001906175,0.0008400562,0.0002652413],"domain_scores_gemma":[0.9970409,0.00001413003,0.0003970929,0.00029783,0.0004174308,0.001832606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0689618,0.03534863,0.1938991,0.000364954,0.07582031,0.007110028,0.001604703,0.0001623979,0.1286964,0.00619516,0.02584946,0.455987],"study_design_scores_gemma":[0.006657606,0.008243548,0.9585051,0.0002924204,0.009853008,0.00007648762,0.0001179454,0.00003960872,0.01132113,0.004403245,0.0002607811,0.0002291505],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828976,0.01493934,0.0001377628,0.0008262982,0.0001430704,0.0003590478,0.00001456714,0.00002779885,0.0006544506],"genre_scores_gemma":[0.9984319,0.0001277755,0.0003024595,0.0003222789,0.0006898391,0.000002194474,0.00006314627,0.00002360568,0.00003682157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.764606,"threshold_uncertainty_score":0.6384618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864110543597465,"score_gpt":0.3335163990951639,"score_spread":0.3048752936591893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}