{"id":"W1955243940","doi":"10.3233/jad-2009-1037","title":"A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor","year":2009,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"PDZ domain; Proteases; Peptide; Chemistry; Intracellular; Cell biology; Serine protease; Protease; Biochemistry; Amyloid beta; Chaperone (clinical); Biology; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434581,0.0003401008,0.0003145849,0.0001434229,0.0001451388,0.0004251014,0.0002832894,0.0003325675,0.00127476],"category_scores_gemma":[0.0001546996,0.00009404719,0.0002719466,0.00008777394,0.0001518637,0.0001463132,0.000120436,0.0003687675,0.0005139237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002289057,"about_ca_system_score_gemma":0.0001302133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003024089,"about_ca_topic_score_gemma":0.0002768335,"domain_scores_codex":[0.9999249,0.00001910205,0.000005638833,0.00002019999,0.00001493601,0.00001527118],"domain_scores_gemma":[0.999933,0.00001627333,0.000009439087,0.00001317773,0.00001114605,0.00001693012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002094854,0.00005911795,0.0002091848,0.00002603204,0.00001650295,0.0001626602,0.0000123266,0.0001318253,0.994324,0.0003507728,0.0001988017,0.004299388],"study_design_scores_gemma":[0.0001015702,0.0006853807,0.002919933,0.000006335843,0.00004617311,0.001862188,0.000008984925,0.003703021,0.977017,0.0001631151,0.01347534,0.00001090165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569963,0.01756629,0.01744239,0.0004961228,0.0001733365,0.00009116284,0.0004593612,0.0003675825,0.006407535],"genre_scores_gemma":[0.9842255,0.002267011,0.006972327,0.0002407628,0.00008067107,0.00004506327,0.0008864197,0.00004351351,0.00523858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127476,"threshold_uncertainty_score":0.004264534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864110543597465,"score_gpt":0.3335163990951639,"score_spread":0.3048752936591893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}